Genetic changes at the Beta-2-Adrenergic receptor locus on chromosome 5 in human colorectal carcinomas

R. Gope, M. L. Gope, A. Thorson, M. Christensen, Thomas Christopher Smyrk, M. Chun, L. Alvarez, D. M. Wildrick, B. M. Boman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Matched normal/tumor DNA pairs from 44 colorectal carcinoma patients were examined for tumor-specific genetic changes using a probe for the beta-2-adrenergic receptor (ADRB2R) gene on chromosome 5. This locus (5q31-q32) maps close to the site of chromosomal deletions recently reported to occur in colorectal carcinomas and distal to the chromosomal location of the familial adenomatous polyposis (FAP) gene (5q21-q22). Our investigation shows tumor-specific allele loss or allelic rearrangement of at least 29% at the AdRb2R locus on chromosome 5 in informative cases. These results suggest that the mechanism by which colorectal carcinomas lose genetic material on chromosome 5 can affect this functional gene located distally to the FAP gene. The possible functional significance that ADRB2R gene changes may have in neoplastic progression is discussed.

Original languageEnglish (US)
Pages (from-to)2047-2050
Number of pages4
JournalAnticancer Research
Volume11
Issue number6
StatePublished - 1991
Externally publishedYes

Fingerprint

Adrenergic beta-2 Receptors
Chromosomes, Human, Pair 5
Colorectal Neoplasms
Genes
Adenomatous Polyposis Coli
Neoplasms
Loss of Heterozygosity
Alleles
DNA

Keywords

  • Beta-2 adrenergic receptor locus
  • Colorectal carcinoma
  • Human chromosome 5

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Gope, R., Gope, M. L., Thorson, A., Christensen, M., Smyrk, T. C., Chun, M., ... Boman, B. M. (1991). Genetic changes at the Beta-2-Adrenergic receptor locus on chromosome 5 in human colorectal carcinomas. Anticancer Research, 11(6), 2047-2050.

Genetic changes at the Beta-2-Adrenergic receptor locus on chromosome 5 in human colorectal carcinomas. / Gope, R.; Gope, M. L.; Thorson, A.; Christensen, M.; Smyrk, Thomas Christopher; Chun, M.; Alvarez, L.; Wildrick, D. M.; Boman, B. M.

In: Anticancer Research, Vol. 11, No. 6, 1991, p. 2047-2050.

Research output: Contribution to journalArticle

Gope, R, Gope, ML, Thorson, A, Christensen, M, Smyrk, TC, Chun, M, Alvarez, L, Wildrick, DM & Boman, BM 1991, 'Genetic changes at the Beta-2-Adrenergic receptor locus on chromosome 5 in human colorectal carcinomas', Anticancer Research, vol. 11, no. 6, pp. 2047-2050.
Gope R, Gope ML, Thorson A, Christensen M, Smyrk TC, Chun M et al. Genetic changes at the Beta-2-Adrenergic receptor locus on chromosome 5 in human colorectal carcinomas. Anticancer Research. 1991;11(6):2047-2050.
Gope, R. ; Gope, M. L. ; Thorson, A. ; Christensen, M. ; Smyrk, Thomas Christopher ; Chun, M. ; Alvarez, L. ; Wildrick, D. M. ; Boman, B. M. / Genetic changes at the Beta-2-Adrenergic receptor locus on chromosome 5 in human colorectal carcinomas. In: Anticancer Research. 1991 ; Vol. 11, No. 6. pp. 2047-2050.
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AU - Chun, M.

AU - Alvarez, L.

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