Genetic changes at the Beta-2-Adrenergic receptor locus on chromosome 5 in human colorectal carcinomas

R. Gope, M. L. Gope, A. Thorson, M. Christensen, T. Smyrk, M. Chun, L. Alvarez, D. M. Wildrick, B. M. Boman

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Matched normal/tumor DNA pairs from 44 colorectal carcinoma patients were examined for tumor-specific genetic changes using a probe for the beta-2-adrenergic receptor (ADRB2R) gene on chromosome 5. This locus (5q31-q32) maps close to the site of chromosomal deletions recently reported to occur in colorectal carcinomas and distal to the chromosomal location of the familial adenomatous polyposis (FAP) gene (5q21-q22). Our investigation shows tumor-specific allele loss or allelic rearrangement of at least 29% at the AdRb2R locus on chromosome 5 in informative cases. These results suggest that the mechanism by which colorectal carcinomas lose genetic material on chromosome 5 can affect this functional gene located distally to the FAP gene. The possible functional significance that ADRB2R gene changes may have in neoplastic progression is discussed.

Original languageEnglish (US)
Pages (from-to)2047-2050
Number of pages4
JournalAnticancer research
Volume11
Issue number6
StatePublished - Dec 1 1991

Keywords

  • Beta-2 adrenergic receptor locus
  • Colorectal carcinoma
  • Human chromosome 5

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Genetic changes at the Beta-2-Adrenergic receptor locus on chromosome 5 in human colorectal carcinomas'. Together they form a unique fingerprint.

  • Cite this

    Gope, R., Gope, M. L., Thorson, A., Christensen, M., Smyrk, T., Chun, M., Alvarez, L., Wildrick, D. M., & Boman, B. M. (1991). Genetic changes at the Beta-2-Adrenergic receptor locus on chromosome 5 in human colorectal carcinomas. Anticancer research, 11(6), 2047-2050.