@article{ad0bd8526c55415c806f794e2c07ad16,
title = "Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus",
abstract = "Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE.",
keywords = "Gene polymorphisms, Leptin pathway, Systemic lupus erythematosus",
author = "{The members of GENLES Network} and {The BIOLUPUS network} and Jian Zhao and Hui Wu and Langefeld, {Carl D.} and Kaufman, {Kenneth M.} and Kelly, {Jennifer A.} and Bae, {Sang Cheol} and Alarc{\'o}n-Riquelme, {Marta E.} and Alarc{\'o}n, {Graciela S.} and Anaya, {Juan Manuel} and Criswell, {Lindsey A.} and Freedman, {Barry I.} and Kamen, {Diane L.} and Gilkeson, {Gary S.} and Jacob, {Chaim O.} and James, {Judith A.} and Merrill, {Joan T.} and Gaffney, {Patrick M.} and Sivils, {Kathy Moser} and Niewold, {Timothy B.} and Petri, {Michelle A.} and Song, {Seung Taek} and Jeong, {Hye jin} and Rosalind Ramsey-Goldman and Reveille, {John D.} and {Hal Scofield}, R. and Stevens, {Anne M.} and Boackle, {Susan A.} and Vil{\'a}, {Luis M.} and Chang, {Deh Ming} and Song, {Yeong Wook} and Vyse, {Timothy J.} and Harley, {John B.} and Brown, {Elizabeth E.} and Edberg, {Jeffrey C.} and Kimberly, {Robert P.} and Hahn, {Bevra H.} and Grossman, {Jennifer M.} and Tsao, {Betty P.} and {La Cava}, Antonio and Johan Frosteg{\aa}rd and Lennart Truedsson and {de Ram{\'o}n}, Enrique and Sabio, {Jos{\'e} M.} and Gonz{\'a}lez-Escribano, {Mar{\'i}a F.} and Javier Martin and Norberto Ortego-Centeno and Callejas, {Jos{\'e} Luis} and Julio S{\'a}nchez-Rom{\'a}n and Sandra D'Alfonso and Sergio Migliarese",
note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
month = dec,
day = "1",
doi = "10.1016/j.clim.2015.09.007",
language = "English (US)",
volume = "161",
pages = "157--162",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",
number = "2",
}