Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus

Jian Zhao, Hui Wu, Carl D. Langefeld, Kenneth M. Kaufman, Jennifer A. Kelly, Sang Cheol Bae, Marta E. Alarcón-Riquelme, Graciela S. Alarcón, Juan Manuel Anaya, Lindsey A. Criswell, Barry I. Freedman, Diane L. Kamen, Gary S. Gilkeson, Chaim O. Jacob, Judith A. James, Joan T. Merrill, Patrick M. Gaffney, Kathy Moser Sivils, Timothy B. Niewold, Michelle A. Petri & 84 others Seung Taek Song, Hye jin Jeong, Rosalind Ramsey-Goldman, John D. Reveille, R. Hal Scofield, Anne M. Stevens, Susan A. Boackle, Luis M. Vilá, Deh Ming Chang, Yeong Wook Song, Timothy J. Vyse, John B. Harley, Elizabeth E. Brown, Jeffrey C. Edberg, Robert P. Kimberly, Bevra H. Hahn, Jennifer M. Grossman, Betty P. Tsao, Antonio La Cava, Johan Frostegård, Lennart Truedsson, Enrique de Ramón, José M. Sabio, María F. González-Escribano, Javier Martin, Norberto Ortego-Centeno, José Luis Callejas, Julio Sánchez-Román, Sandra D'Alfonso, Sergio Migliarese, Gian Domenico Sebastiani, Mauro Galeazzi, Torsten Witte, Bernard R. Lauwerys, Emoke Endreffy, László Kovács, Carlos Vasconcelos, Berta Martins da Silva, Hugo R. Scherbarth, Pilar C. Marino, Estela L. Motta, Susana Gamron, Cristina Drenkard, Emilia Menso, Alberto Allievi, Guillermo A. Tate, Jose L. Presas, Simon A. Palatnik, Marcelo Abdala, Mariela Bearzotti, Alejandro Alvarellos, Francisco Caeiro, Ana Bertoli, Sergio Paira, Susana Roverano, Cesar E. Graf, Estela Bertero, Cesar Caprarulo, Griselda Buchanan, Carolina Guillerón, Sebastian Grimaudo, Jorge Manni, Luis J. Catoggio, Enrique R. Soriano, Carlos D. Santos, Cristina Prigione, Fernando A. Ramos, Sandra M. Navarro, Guillermo A. Berbotto, Marisa Jorfen, Elisa J. Romero, Mercedes A. Garcia, Juan C. Marcos, Ana I. Marcos, Carlos E. Perandones, Alicia Eimon, Sanatorio Parque, Cristina G. Battagliotti, Eduardo Acevedo, Mariano Cucho, Ignacio García de la Torre, Mario Cardiel Ríos, Francisco Moctezuma, Marco Maradiaga Ceceña

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalClinical Immunology
Volume161
Issue number2
DOIs
StatePublished - Dec 1 2015

Fingerprint

Leptin
Systemic Lupus Erythematosus
Genetic Association Studies
Genetic Predisposition to Disease
Single Nucleotide Polymorphism
DNA
Genes

Keywords

  • Gene polymorphisms
  • Leptin pathway
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Zhao, J., Wu, H., Langefeld, C. D., Kaufman, K. M., Kelly, J. A., Bae, S. C., ... Maradiaga Ceceña, M. (2015). Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus. Clinical Immunology, 161(2), 157-162. https://doi.org/10.1016/j.clim.2015.09.007

Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus. / Zhao, Jian; Wu, Hui; Langefeld, Carl D.; Kaufman, Kenneth M.; Kelly, Jennifer A.; Bae, Sang Cheol; Alarcón-Riquelme, Marta E.; Alarcón, Graciela S.; Anaya, Juan Manuel; Criswell, Lindsey A.; Freedman, Barry I.; Kamen, Diane L.; Gilkeson, Gary S.; Jacob, Chaim O.; James, Judith A.; Merrill, Joan T.; Gaffney, Patrick M.; Sivils, Kathy Moser; Niewold, Timothy B.; Petri, Michelle A.; Song, Seung Taek; Jeong, Hye jin; Ramsey-Goldman, Rosalind; Reveille, John D.; Hal Scofield, R.; Stevens, Anne M.; Boackle, Susan A.; Vilá, Luis M.; Chang, Deh Ming; Song, Yeong Wook; Vyse, Timothy J.; Harley, John B.; Brown, Elizabeth E.; Edberg, Jeffrey C.; Kimberly, Robert P.; Hahn, Bevra H.; Grossman, Jennifer M.; Tsao, Betty P.; La Cava, Antonio; Frostegård, Johan; Truedsson, Lennart; de Ramón, Enrique; Sabio, José M.; González-Escribano, María F.; Martin, Javier; Ortego-Centeno, Norberto; Callejas, José Luis; Sánchez-Román, Julio; D'Alfonso, Sandra; Migliarese, Sergio; Sebastiani, Gian Domenico; Galeazzi, Mauro; Witte, Torsten; Lauwerys, Bernard R.; Endreffy, Emoke; Kovács, László; Vasconcelos, Carlos; da Silva, Berta Martins; Scherbarth, Hugo R.; Marino, Pilar C.; Motta, Estela L.; Gamron, Susana; Drenkard, Cristina; Menso, Emilia; Allievi, Alberto; Tate, Guillermo A.; Presas, Jose L.; Palatnik, Simon A.; Abdala, Marcelo; Bearzotti, Mariela; Alvarellos, Alejandro; Caeiro, Francisco; Bertoli, Ana; Paira, Sergio; Roverano, Susana; Graf, Cesar E.; Bertero, Estela; Caprarulo, Cesar; Buchanan, Griselda; Guillerón, Carolina; Grimaudo, Sebastian; Manni, Jorge; Catoggio, Luis J.; Soriano, Enrique R.; Santos, Carlos D.; Prigione, Cristina; Ramos, Fernando A.; Navarro, Sandra M.; Berbotto, Guillermo A.; Jorfen, Marisa; Romero, Elisa J.; Garcia, Mercedes A.; Marcos, Juan C.; Marcos, Ana I.; Perandones, Carlos E.; Eimon, Alicia; Parque, Sanatorio; Battagliotti, Cristina G.; Acevedo, Eduardo; Cucho, Mariano; de la Torre, Ignacio García; Ríos, Mario Cardiel; Moctezuma, Francisco; Maradiaga Ceceña, Marco.

In: Clinical Immunology, Vol. 161, No. 2, 01.12.2015, p. 157-162.

Research output: Contribution to journalArticle

Zhao, J, Wu, H, Langefeld, CD, Kaufman, KM, Kelly, JA, Bae, SC, Alarcón-Riquelme, ME, Alarcón, GS, Anaya, JM, Criswell, LA, Freedman, BI, Kamen, DL, Gilkeson, GS, Jacob, CO, James, JA, Merrill, JT, Gaffney, PM, Sivils, KM, Niewold, TB, Petri, MA, Song, ST, Jeong, HJ, Ramsey-Goldman, R, Reveille, JD, Hal Scofield, R, Stevens, AM, Boackle, SA, Vilá, LM, Chang, DM, Song, YW, Vyse, TJ, Harley, JB, Brown, EE, Edberg, JC, Kimberly, RP, Hahn, BH, Grossman, JM, Tsao, BP, La Cava, A, Frostegård, J, Truedsson, L, de Ramón, E, Sabio, JM, González-Escribano, MF, Martin, J, Ortego-Centeno, N, Callejas, JL, Sánchez-Román, J, D'Alfonso, S, Migliarese, S, Sebastiani, GD, Galeazzi, M, Witte, T, Lauwerys, BR, Endreffy, E, Kovács, L, Vasconcelos, C, da Silva, BM, Scherbarth, HR, Marino, PC, Motta, EL, Gamron, S, Drenkard, C, Menso, E, Allievi, A, Tate, GA, Presas, JL, Palatnik, SA, Abdala, M, Bearzotti, M, Alvarellos, A, Caeiro, F, Bertoli, A, Paira, S, Roverano, S, Graf, CE, Bertero, E, Caprarulo, C, Buchanan, G, Guillerón, C, Grimaudo, S, Manni, J, Catoggio, LJ, Soriano, ER, Santos, CD, Prigione, C, Ramos, FA, Navarro, SM, Berbotto, GA, Jorfen, M, Romero, EJ, Garcia, MA, Marcos, JC, Marcos, AI, Perandones, CE, Eimon, A, Parque, S, Battagliotti, CG, Acevedo, E, Cucho, M, de la Torre, IG, Ríos, MC, Moctezuma, F & Maradiaga Ceceña, M 2015, 'Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus', Clinical Immunology, vol. 161, no. 2, pp. 157-162. https://doi.org/10.1016/j.clim.2015.09.007
Zhao, Jian ; Wu, Hui ; Langefeld, Carl D. ; Kaufman, Kenneth M. ; Kelly, Jennifer A. ; Bae, Sang Cheol ; Alarcón-Riquelme, Marta E. ; Alarcón, Graciela S. ; Anaya, Juan Manuel ; Criswell, Lindsey A. ; Freedman, Barry I. ; Kamen, Diane L. ; Gilkeson, Gary S. ; Jacob, Chaim O. ; James, Judith A. ; Merrill, Joan T. ; Gaffney, Patrick M. ; Sivils, Kathy Moser ; Niewold, Timothy B. ; Petri, Michelle A. ; Song, Seung Taek ; Jeong, Hye jin ; Ramsey-Goldman, Rosalind ; Reveille, John D. ; Hal Scofield, R. ; Stevens, Anne M. ; Boackle, Susan A. ; Vilá, Luis M. ; Chang, Deh Ming ; Song, Yeong Wook ; Vyse, Timothy J. ; Harley, John B. ; Brown, Elizabeth E. ; Edberg, Jeffrey C. ; Kimberly, Robert P. ; Hahn, Bevra H. ; Grossman, Jennifer M. ; Tsao, Betty P. ; La Cava, Antonio ; Frostegård, Johan ; Truedsson, Lennart ; de Ramón, Enrique ; Sabio, José M. ; González-Escribano, María F. ; Martin, Javier ; Ortego-Centeno, Norberto ; Callejas, José Luis ; Sánchez-Román, Julio ; D'Alfonso, Sandra ; Migliarese, Sergio ; Sebastiani, Gian Domenico ; Galeazzi, Mauro ; Witte, Torsten ; Lauwerys, Bernard R. ; Endreffy, Emoke ; Kovács, László ; Vasconcelos, Carlos ; da Silva, Berta Martins ; Scherbarth, Hugo R. ; Marino, Pilar C. ; Motta, Estela L. ; Gamron, Susana ; Drenkard, Cristina ; Menso, Emilia ; Allievi, Alberto ; Tate, Guillermo A. ; Presas, Jose L. ; Palatnik, Simon A. ; Abdala, Marcelo ; Bearzotti, Mariela ; Alvarellos, Alejandro ; Caeiro, Francisco ; Bertoli, Ana ; Paira, Sergio ; Roverano, Susana ; Graf, Cesar E. ; Bertero, Estela ; Caprarulo, Cesar ; Buchanan, Griselda ; Guillerón, Carolina ; Grimaudo, Sebastian ; Manni, Jorge ; Catoggio, Luis J. ; Soriano, Enrique R. ; Santos, Carlos D. ; Prigione, Cristina ; Ramos, Fernando A. ; Navarro, Sandra M. ; Berbotto, Guillermo A. ; Jorfen, Marisa ; Romero, Elisa J. ; Garcia, Mercedes A. ; Marcos, Juan C. ; Marcos, Ana I. ; Perandones, Carlos E. ; Eimon, Alicia ; Parque, Sanatorio ; Battagliotti, Cristina G. ; Acevedo, Eduardo ; Cucho, Mariano ; de la Torre, Ignacio García ; Ríos, Mario Cardiel ; Moctezuma, Francisco ; Maradiaga Ceceña, Marco. / Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus. In: Clinical Immunology. 2015 ; Vol. 161, No. 2. pp. 157-162.
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T1 - Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus

AU - Zhao, Jian

AU - Wu, Hui

AU - Langefeld, Carl D.

AU - Kaufman, Kenneth M.

AU - Kelly, Jennifer A.

AU - Bae, Sang Cheol

AU - Alarcón-Riquelme, Marta E.

AU - Alarcón, Graciela S.

AU - Anaya, Juan Manuel

AU - Criswell, Lindsey A.

AU - Freedman, Barry I.

AU - Kamen, Diane L.

AU - Gilkeson, Gary S.

AU - Jacob, Chaim O.

AU - James, Judith A.

AU - Merrill, Joan T.

AU - Gaffney, Patrick M.

AU - Sivils, Kathy Moser

AU - Niewold, Timothy B.

AU - Petri, Michelle A.

AU - Song, Seung Taek

AU - Jeong, Hye jin

AU - Ramsey-Goldman, Rosalind

AU - Reveille, John D.

AU - Hal Scofield, R.

AU - Stevens, Anne M.

AU - Boackle, Susan A.

AU - Vilá, Luis M.

AU - Chang, Deh Ming

AU - Song, Yeong Wook

AU - Vyse, Timothy J.

AU - Harley, John B.

AU - Brown, Elizabeth E.

AU - Edberg, Jeffrey C.

AU - Kimberly, Robert P.

AU - Hahn, Bevra H.

AU - Grossman, Jennifer M.

AU - Tsao, Betty P.

AU - La Cava, Antonio

AU - Frostegård, Johan

AU - Truedsson, Lennart

AU - de Ramón, Enrique

AU - Sabio, José M.

AU - González-Escribano, María F.

AU - Martin, Javier

AU - Ortego-Centeno, Norberto

AU - Callejas, José Luis

AU - Sánchez-Román, Julio

AU - D'Alfonso, Sandra

AU - Migliarese, Sergio

AU - Sebastiani, Gian Domenico

AU - Galeazzi, Mauro

AU - Witte, Torsten

AU - Lauwerys, Bernard R.

AU - Endreffy, Emoke

AU - Kovács, László

AU - Vasconcelos, Carlos

AU - da Silva, Berta Martins

AU - Scherbarth, Hugo R.

AU - Marino, Pilar C.

AU - Motta, Estela L.

AU - Gamron, Susana

AU - Drenkard, Cristina

AU - Menso, Emilia

AU - Allievi, Alberto

AU - Tate, Guillermo A.

AU - Presas, Jose L.

AU - Palatnik, Simon A.

AU - Abdala, Marcelo

AU - Bearzotti, Mariela

AU - Alvarellos, Alejandro

AU - Caeiro, Francisco

AU - Bertoli, Ana

AU - Paira, Sergio

AU - Roverano, Susana

AU - Graf, Cesar E.

AU - Bertero, Estela

AU - Caprarulo, Cesar

AU - Buchanan, Griselda

AU - Guillerón, Carolina

AU - Grimaudo, Sebastian

AU - Manni, Jorge

AU - Catoggio, Luis J.

AU - Soriano, Enrique R.

AU - Santos, Carlos D.

AU - Prigione, Cristina

AU - Ramos, Fernando A.

AU - Navarro, Sandra M.

AU - Berbotto, Guillermo A.

AU - Jorfen, Marisa

AU - Romero, Elisa J.

AU - Garcia, Mercedes A.

AU - Marcos, Juan C.

AU - Marcos, Ana I.

AU - Perandones, Carlos E.

AU - Eimon, Alicia

AU - Parque, Sanatorio

AU - Battagliotti, Cristina G.

AU - Acevedo, Eduardo

AU - Cucho, Mariano

AU - de la Torre, Ignacio García

AU - Ríos, Mario Cardiel

AU - Moctezuma, Francisco

AU - Maradiaga Ceceña, Marco

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE.

AB - Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE.

KW - Gene polymorphisms

KW - Leptin pathway

KW - Systemic lupus erythematosus

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U2 - 10.1016/j.clim.2015.09.007

DO - 10.1016/j.clim.2015.09.007

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SP - 157

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JO - Clinical Immunology

JF - Clinical Immunology

SN - 1521-6616

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