Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus

Jian Zhao, Hui Wu, Carl D. Langefeld, Kenneth M. Kaufman, Jennifer A. Kelly, Sang Cheol Bae, Marta E. Alarcón-Riquelme, Graciela S. Alarcón, Juan Manuel Anaya, Lindsey A. Criswell, Barry I. Freedman, Diane L. Kamen, Gary S. Gilkeson, Chaim O. Jacob, Judith A. James, Joan T. Merrill, Patrick M. Gaffney, Kathy Moser Sivils, Timothy B. Niewold, Michelle A. PetriSeung Taek Song, Hye jin Jeong, Rosalind Ramsey-Goldman, John D. Reveille, R. Hal Scofield, Anne M. Stevens, Susan A. Boackle, Luis M. Vilá, Deh Ming Chang, Yeong Wook Song, Timothy J. Vyse, John B. Harley, Elizabeth E. Brown, Jeffrey C. Edberg, Robert P. Kimberly, Bevra H. Hahn, Jennifer M. Grossman, Betty P. Tsao, Antonio La Cava, Johan Frostegård, Lennart Truedsson, Enrique de Ramón, José M. Sabio, María F. González-Escribano, Javier Martin, Norberto Ortego-Centeno, José Luis Callejas, Julio Sánchez-Román, Sandra D'Alfonso, Sergio Migliarese, Gian Domenico Sebastiani, Mauro Galeazzi, Torsten Witte, Bernard R. Lauwerys, Emoke Endreffy, László Kovács, Carlos Vasconcelos, Berta Martins da Silva, Hugo R. Scherbarth, Pilar C. Marino, Estela L. Motta, Susana Gamron, Cristina Drenkard, Emilia Menso, Alberto Allievi, Guillermo A. Tate, Jose L. Presas, Simon A. Palatnik, Marcelo Abdala, Mariela Bearzotti, Alejandro Alvarellos, Francisco Caeiro, Ana Bertoli, Sergio Paira, Susana Roverano, Cesar E. Graf, Estela Bertero, Cesar Caprarulo, Griselda Buchanan, Carolina Guillerón, Sebastian Grimaudo, Jorge Manni, Luis J. Catoggio, Enrique R. Soriano, Carlos D. Santos, Cristina Prigione, Fernando A. Ramos, Sandra M. Navarro, Guillermo A. Berbotto, Marisa Jorfen, Elisa J. Romero, Mercedes A. Garcia, Juan C. Marcos, Ana I. Marcos, Carlos E. Perandones, Alicia Eimon, Sanatorio Parque, Cristina G. Battagliotti, Eduardo Acevedo, Mariano Cucho, Ignacio García de la Torre, Mario Cardiel Ríos, Francisco Moctezuma, Marco Maradiaga Ceceña

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Abstract

Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalClinical Immunology
Volume161
Issue number2
DOIs
StatePublished - Dec 1 2015

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Keywords

  • Gene polymorphisms
  • Leptin pathway
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Zhao, J., Wu, H., Langefeld, C. D., Kaufman, K. M., Kelly, J. A., Bae, S. C., Alarcón-Riquelme, M. E., Alarcón, G. S., Anaya, J. M., Criswell, L. A., Freedman, B. I., Kamen, D. L., Gilkeson, G. S., Jacob, C. O., James, J. A., Merrill, J. T., Gaffney, P. M., Sivils, K. M., Niewold, T. B., ... Maradiaga Ceceña, M. (2015). Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus. Clinical Immunology, 161(2), 157-162. https://doi.org/10.1016/j.clim.2015.09.007