Genetic ancestry, serum interferon- αactivity, and autoantibodies in systemic lupus erythematosus

Kichul Ko, Beverly S. Franek, Miranda Marion, Kenneth M. Kaufman, Carl D. Langefeld, John B. Harley, Timothy B. Niewold

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Objective. To investigate and refine the relationships among systemic lupus erythematosus (SLE) and related autoantibodies, interferon-α (IFN-α), and various ancestral backgrounds. Methods. We investigated quantitatively defined genetic ancestry through principal component analysis in place of self-reported ancestry. Results. African ancestry was found to be associated with presence of anti-RNP antibody (p = 0.0026), and anti-RNP was correlated with high levels of IFN-α (p = 2.8 × 10 -5). Conclusion. Our data support a model in which African ancestry increases the likelihood of SLE-associated autoantibody formation, which subsequently results in higher levels of serum IFN-α. The Journal of Rheumatology

Original languageEnglish (US)
Pages (from-to)1238-1240
Number of pages3
JournalJournal of Rheumatology
Volume39
Issue number6
DOIs
StatePublished - Jun 2012

Keywords

  • Autoantibodies
  • Genetics
  • Interferons
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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