Genetic ancestry, serum interferon- αactivity, and autoantibodies in systemic lupus erythematosus

Kichul Ko, Beverly S. Franek, Miranda Marion, Kenneth M. Kaufman, Carl D. Langefeld, John B. Harley, Timothy B. Niewold

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective. To investigate and refine the relationships among systemic lupus erythematosus (SLE) and related autoantibodies, interferon-α (IFN-α), and various ancestral backgrounds. Methods. We investigated quantitatively defined genetic ancestry through principal component analysis in place of self-reported ancestry. Results. African ancestry was found to be associated with presence of anti-RNP antibody (p = 0.0026), and anti-RNP was correlated with high levels of IFN-α (p = 2.8 × 10 -5). Conclusion. Our data support a model in which African ancestry increases the likelihood of SLE-associated autoantibody formation, which subsequently results in higher levels of serum IFN-α. The Journal of Rheumatology

Original languageEnglish (US)
Pages (from-to)1238-1240
Number of pages3
JournalJournal of Rheumatology
Volume39
Issue number6
DOIs
StatePublished - Jun 2012
Externally publishedYes

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Systemic Lupus Erythematosus
Autoantibodies
Interferons
Serum
Rheumatology
Principal Component Analysis
Anti-Idiotypic Antibodies

Keywords

  • Autoantibodies
  • Genetics
  • Interferons
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Ko, K., Franek, B. S., Marion, M., Kaufman, K. M., Langefeld, C. D., Harley, J. B., & Niewold, T. B. (2012). Genetic ancestry, serum interferon- αactivity, and autoantibodies in systemic lupus erythematosus. Journal of Rheumatology, 39(6), 1238-1240. https://doi.org/10.3899/jrheum.111467

Genetic ancestry, serum interferon- αactivity, and autoantibodies in systemic lupus erythematosus. / Ko, Kichul; Franek, Beverly S.; Marion, Miranda; Kaufman, Kenneth M.; Langefeld, Carl D.; Harley, John B.; Niewold, Timothy B.

In: Journal of Rheumatology, Vol. 39, No. 6, 06.2012, p. 1238-1240.

Research output: Contribution to journalArticle

Ko, K, Franek, BS, Marion, M, Kaufman, KM, Langefeld, CD, Harley, JB & Niewold, TB 2012, 'Genetic ancestry, serum interferon- αactivity, and autoantibodies in systemic lupus erythematosus', Journal of Rheumatology, vol. 39, no. 6, pp. 1238-1240. https://doi.org/10.3899/jrheum.111467
Ko, Kichul ; Franek, Beverly S. ; Marion, Miranda ; Kaufman, Kenneth M. ; Langefeld, Carl D. ; Harley, John B. ; Niewold, Timothy B. / Genetic ancestry, serum interferon- αactivity, and autoantibodies in systemic lupus erythematosus. In: Journal of Rheumatology. 2012 ; Vol. 39, No. 6. pp. 1238-1240.
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