Genetic ancestry, serum interferon- αactivity, and autoantibodies in systemic lupus erythematosus

Kichul Ko; Beverly S. Franek; Miranda Marion; Kenneth M. Kaufman; Carl D. Langefeld; John B. Harley; Timothy B. Niewold

doi:10.3899/jrheum.111467

Genetic ancestry, serum interferon- αactivity, and autoantibodies in systemic lupus erythematosus

Kichul Ko, Beverly S. Franek, Miranda Marion, Kenneth M. Kaufman, Carl D. Langefeld, John B. Harley, Timothy B. Niewold

Rheumatology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Objective. To investigate and refine the relationships among systemic lupus erythematosus (SLE) and related autoantibodies, interferon-α (IFN-α), and various ancestral backgrounds. Methods. We investigated quantitatively defined genetic ancestry through principal component analysis in place of self-reported ancestry. Results. African ancestry was found to be associated with presence of anti-RNP antibody (p = 0.0026), and anti-RNP was correlated with high levels of IFN-α (p = 2.8 × 10 ^-5). Conclusion. Our data support a model in which African ancestry increases the likelihood of SLE-associated autoantibody formation, which subsequently results in higher levels of serum IFN-α. The Journal of Rheumatology

Original language	English (US)
Pages (from-to)	1238-1240
Number of pages	3
Journal	Journal of Rheumatology
Volume	39
Issue number	6
DOIs	https://doi.org/10.3899/jrheum.111467
State	Published - Jun 2012

Keywords

Autoantibodies
Genetics
Interferons
Systemic lupus erythematosus

ASJC Scopus subject areas

Rheumatology
Immunology and Allergy
Immunology

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10.3899/jrheum.111467

Cite this

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title = "Genetic ancestry, serum interferon- αactivity, and autoantibodies in systemic lupus erythematosus",

abstract = "Objective. To investigate and refine the relationships among systemic lupus erythematosus (SLE) and related autoantibodies, interferon-α (IFN-α), and various ancestral backgrounds. Methods. We investigated quantitatively defined genetic ancestry through principal component analysis in place of self-reported ancestry. Results. African ancestry was found to be associated with presence of anti-RNP antibody (p = 0.0026), and anti-RNP was correlated with high levels of IFN-α (p = 2.8 × 10 -5). Conclusion. Our data support a model in which African ancestry increases the likelihood of SLE-associated autoantibody formation, which subsequently results in higher levels of serum IFN-α. The Journal of Rheumatology",

keywords = "Autoantibodies, Genetics, Interferons, Systemic lupus erythematosus",

author = "Kichul Ko and Franek, {Beverly S.} and Miranda Marion and Kaufman, {Kenneth M.} and Langefeld, {Carl D.} and Harley, {John B.} and Niewold, {Timothy B.}",

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language = "English (US)",

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T1 - Genetic ancestry, serum interferon- αactivity, and autoantibodies in systemic lupus erythematosus

AU - Ko, Kichul

AU - Franek, Beverly S.

AU - Marion, Miranda

AU - Kaufman, Kenneth M.

AU - Langefeld, Carl D.

AU - Harley, John B.

AU - Niewold, Timothy B.

PY - 2012/6

Y1 - 2012/6

N2 - Objective. To investigate and refine the relationships among systemic lupus erythematosus (SLE) and related autoantibodies, interferon-α (IFN-α), and various ancestral backgrounds. Methods. We investigated quantitatively defined genetic ancestry through principal component analysis in place of self-reported ancestry. Results. African ancestry was found to be associated with presence of anti-RNP antibody (p = 0.0026), and anti-RNP was correlated with high levels of IFN-α (p = 2.8 × 10 -5). Conclusion. Our data support a model in which African ancestry increases the likelihood of SLE-associated autoantibody formation, which subsequently results in higher levels of serum IFN-α. The Journal of Rheumatology

AB - Objective. To investigate and refine the relationships among systemic lupus erythematosus (SLE) and related autoantibodies, interferon-α (IFN-α), and various ancestral backgrounds. Methods. We investigated quantitatively defined genetic ancestry through principal component analysis in place of self-reported ancestry. Results. African ancestry was found to be associated with presence of anti-RNP antibody (p = 0.0026), and anti-RNP was correlated with high levels of IFN-α (p = 2.8 × 10 -5). Conclusion. Our data support a model in which African ancestry increases the likelihood of SLE-associated autoantibody formation, which subsequently results in higher levels of serum IFN-α. The Journal of Rheumatology

KW - Autoantibodies

KW - Genetics

KW - Interferons

KW - Systemic lupus erythematosus

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Genetic ancestry, serum interferon- αactivity, and autoantibodies in systemic lupus erythematosus

Abstract

Keywords

ASJC Scopus subject areas

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