Genetic analysis of mammographic breast density in adult women: Evidence of a gene effect

James S. Pankow, Celine M Vachon, Christopher C. Kuni, Richard A. King, Donna K. Arnett, Dawn M. Grabrick, Stephen S. Rich, V. Elving Anderson, Thomas A. Sellers

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Background: The appearance of the female breast viewed by mammography varies considerably from one individual to another because of underlying differences in the relative proportions of fat, connective tissue, and glandular epithelium that combine to create a characteristic pattern of breast density. An association between mammographic patterns and family history of breast cancer has previously been reported. However, this association has not been found in all studies, and few data are available on possible genetic components contributing to mammographic breast density. Purpose: Our purpose was to estimate familial correlations and perform complex genetic segregation analyses to test the hypothesis that the transmission of a major gene influences mammographic breast density. Methods: As part of a cohort study (initiated in 1944) of families with a history of breast cancer, the probands' female relatives who were older than 40 years were asked to obtain a routine mammogram. The mammograms of 1370 women from 258 independent families were analyzed. The fraction of the breast volume occupied by radiographically dense tissue was estimated visually from video displays of left or right mediolateral oblique views by one radiologist experienced in mammography who had no knowledge of individual relationships to the probands. Data on breast cancer risk factors were obtained through telephone interviews and mailed questionnaires. Unadjusted and adjusted familial correlations in breast density were calculated, and complex genetic segregation analyses were performed. Results: Sister-sister correlations in breast density (unadjusted and adjusted for age and either body mass index, menopausal status, hormone replacement therapy, waist-to-hip ratio, number of live births, alcohol consumption, or cigarette smoking status) were all statistically significant (r = .16-.27; all P<.05 [two-sided]). Estimated mother-daughter correlations were smaller in magnitude (r = .01-.17) and not statistically significant. Segregation analyses indicate that a major autosomal gene influences breast density. The mendelian transmission of a dominant gene provided the best fit to the data; however, hypotheses involving the inheritance of either a recessive gene or a codominant gene could not be ruled out. The mendelian dominant hypothesis, accounting for 29% of the variability in breast density, suggests that approximately 12% of the population would be expected to carry at least one variant allele of this putative gene. Women who inherit the variant allele would have a mean breast density about twice that of the rest of the population. Conclusions: Our preliminary findings suggest that, in this cohort of women at risk of breast cancer, mammographic breast density may be genetically influenced.

Original languageEnglish (US)
Pages (from-to)549-556
Number of pages8
JournalJournal of the National Cancer Institute
Volume89
Issue number8
StatePublished - Apr 16 1997
Externally publishedYes

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Genes
Breast Neoplasms
Mammography
Siblings
Breast
Alleles
Recessive Genes
Breast Density
Dominant Genes
Waist-Hip Ratio
Hormone Replacement Therapy
Live Birth
Nuclear Family
Alcohol Drinking
Connective Tissue
Population
Body Mass Index
Cohort Studies
Epithelium
Smoking

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pankow, J. S., Vachon, C. M., Kuni, C. C., King, R. A., Arnett, D. K., Grabrick, D. M., ... Sellers, T. A. (1997). Genetic analysis of mammographic breast density in adult women: Evidence of a gene effect. Journal of the National Cancer Institute, 89(8), 549-556.

Genetic analysis of mammographic breast density in adult women : Evidence of a gene effect. / Pankow, James S.; Vachon, Celine M; Kuni, Christopher C.; King, Richard A.; Arnett, Donna K.; Grabrick, Dawn M.; Rich, Stephen S.; Anderson, V. Elving; Sellers, Thomas A.

In: Journal of the National Cancer Institute, Vol. 89, No. 8, 16.04.1997, p. 549-556.

Research output: Contribution to journalArticle

Pankow, JS, Vachon, CM, Kuni, CC, King, RA, Arnett, DK, Grabrick, DM, Rich, SS, Anderson, VE & Sellers, TA 1997, 'Genetic analysis of mammographic breast density in adult women: Evidence of a gene effect', Journal of the National Cancer Institute, vol. 89, no. 8, pp. 549-556.
Pankow, James S. ; Vachon, Celine M ; Kuni, Christopher C. ; King, Richard A. ; Arnett, Donna K. ; Grabrick, Dawn M. ; Rich, Stephen S. ; Anderson, V. Elving ; Sellers, Thomas A. / Genetic analysis of mammographic breast density in adult women : Evidence of a gene effect. In: Journal of the National Cancer Institute. 1997 ; Vol. 89, No. 8. pp. 549-556.
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AU - Vachon, Celine M

AU - Kuni, Christopher C.

AU - King, Richard A.

AU - Arnett, Donna K.

AU - Grabrick, Dawn M.

AU - Rich, Stephen S.

AU - Anderson, V. Elving

AU - Sellers, Thomas A.

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