Genetic analysis of juvenile periodontitis in families ascertained through an affected proband

T. H. Beaty, J. A. Boughman, P. Yang, J. A. Astemborski, J. B. Suzuki

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Abstract

Data from 28 families ascertained through a proband with juvenile periodontitis were used to test a series of Mendelian models of inheritance that included both autosomal and X-linked transmission. There was strong evidence of familial aggregation of this progressive dental disease, and the best-fitting model was an autosomal recessive model. Because of the rather limited age range for expression of the disease in this situation, simulations were done, in a model-choice analysis using samples of this size, to assess the chance of mistaking an autosomal dominant disease (with masking of the affected phenotype outside a specified age range) for an autosomal recessive disease. While the rate of Type II error was fairly high (40%) when competing models in these simulations were compared, these data suggest that it is reasonable to infer that juvenile periodontitis is an autosomal recessive disorder.

Original languageEnglish (US)
Pages (from-to)443-452
Number of pages10
JournalAmerican journal of human genetics
Volume40
Issue number5
StatePublished - Sep 2 1987

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Beaty, T. H., Boughman, J. A., Yang, P., Astemborski, J. A., & Suzuki, J. B. (1987). Genetic analysis of juvenile periodontitis in families ascertained through an affected proband. American journal of human genetics, 40(5), 443-452.