Abstract
Data from 28 families ascertained through a proband with juvenile periodontitis were used to test a series of Mendelian models of inheritance that included both autosomal and X-linked transmission. There was strong evidence of familial aggregation of this progressive dental disease, and the best-fitting model was an autosomal recessive model. Because of the rather limited age range for expression of the disease in this situation, simulations were done, in a model-choice analysis using samples of this size, to assess the chance of mistaking an autosomal dominant disease (with masking of the affected phenotype outside a specified age range) for an autosomal recessive disease. While the rate of Type II error was fairly high (40%) when competing models in these simulations were compared, these data suggest that it is reasonable to infer that juvenile periodontitis is an autosomal recessive disorder.
Original language | English (US) |
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Pages (from-to) | 443-452 |
Number of pages | 10 |
Journal | American journal of human genetics |
Volume | 40 |
Issue number | 5 |
State | Published - 1987 |
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)