Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex

Robert V. Blanden, Peter C. Doherty, Malcolm B.C. Dunlop, Ian D. Gardner, Rolf M. Zinkernagel, Chella S. David

Research output: Contribution to journalArticlepeer-review

149 Scopus citations

Abstract

EVIDENCE is mounting that in mice, certain specific immunological effector functions of thymus-derived (T) lymphocytes are efficient only when donors of T cells and the cells with which they interact have at least a part of the H-2 gene complex in common1-8. Examples include T helper function in vivo and in vitro1-3, cytotoxicity mediated by T cells against virus-infected4-6 or TNP-modified7 target cells in vitro, immunopathology mediated by T cells4, or protection against bacterial8 and viral infection6 in vivo. This requirement for H-2 compatibility has been studied in detail by measuring the cytotoxicity of T cells from donors immunised with either lymphocytic choriomeningitis (LCM) or ectromelia virus using target cells infected with the homologus virus.

Original languageEnglish (US)
Pages (from-to)269-270
Number of pages2
JournalNature
Volume254
Issue number5497
DOIs
StatePublished - 1975

ASJC Scopus subject areas

  • General

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