Genes for MHC, TCR and MIs determine susceptibility to collagen induced arthritis

C. S. David

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Type II collagen induced arthritis (CIA) in mice is an animal model for polyarthritis. The susceptibility to the disease is linked to the class II genes of H-2 gene complex (MHC). The susceptibility requires T cells expressing certain receptors coded by the V(β) genes. Further, the MIs gene products in combination with the class II molecules can up- or down-regulate the T cells involved in the disease. The disease is mediated by the presentation of an arthritogenic epitope on the collagen type II peptide by the MHC class II molecule, which is recognized by a T cell expressing certain V(β) receptors, triggering the autoimmune response. These studies point out possible mechanisms of rheumatoid arthritis in humans and suggest various methods of immune intervention to down-regulate the disease.

Original languageEnglish (US)
Pages (from-to)575-584
Number of pages10
JournalAPMIS
Volume98
Issue number7
DOIs
StatePublished - Jan 1 1990

Keywords

  • T-cell receptor
  • arthritogenic epitope
  • class II molecule
  • clonal deletion
  • type II collagen

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Microbiology (medical)

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