Genes and irritable bowel syndrome: Is there a link?

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Advances in genetics and genomics during the past decade, including sequencing of the human genome and DNA sequencing technologies, have made it possible to discover the genetic basis for many diseases. With the discovery of multiple genetic loci for gastrointestinal diseases such as Crohn's disease, some have begun to wonder-Could there be a genetic basis for irritable bowel syndrome (IBS)? This article summarizes the evidence for and against a link between genes and IBS. In addition, a gene-environment paradigm is presented to combine the two opposing hypotheses, as IBS may represent a complex genetic disorder that results from the interaction of several genes and environmental risk factors.

Original languageEnglish (US)
Pages (from-to)355-362
Number of pages8
JournalCurrent Gastroenterology Reports
Volume10
Issue number4
DOIs
StatePublished - 2008

Fingerprint

Irritable Bowel Syndrome
Genes
Inborn Genetic Diseases
Genetic Loci
Gastrointestinal Diseases
Human Genome
Genomics
DNA Sequence Analysis
Crohn Disease
Technology

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Genes and irritable bowel syndrome : Is there a link? / Saito Loftus, Yuri Ann.

In: Current Gastroenterology Reports, Vol. 10, No. 4, 2008, p. 355-362.

Research output: Contribution to journalArticle

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