TY - JOUR
T1 - Genes and irritable bowel syndrome
T2 - Is there a link?
AU - Saito, Yuri A.
N1 - Funding Information:
Dr. Saito is grateful to Lori R. Anderson for her assistance in preparing this manuscript. Dr. Saito has been supported by research grants from the National Institutes of Health (DK-66271 and DK-76797).
Funding Information:
Dr. Saito has received an unrestricted research grant from Solvay Pharmaceuticals and is a consultant for Salix Pharmaceuticals.
PY - 2008
Y1 - 2008
N2 - Advances in genetics and genomics during the past decade, including sequencing of the human genome and DNA sequencing technologies, have made it possible to discover the genetic basis for many diseases. With the discovery of multiple genetic loci for gastrointestinal diseases such as Crohn's disease, some have begun to wonder-Could there be a genetic basis for irritable bowel syndrome (IBS)? This article summarizes the evidence for and against a link between genes and IBS. In addition, a gene-environment paradigm is presented to combine the two opposing hypotheses, as IBS may represent a complex genetic disorder that results from the interaction of several genes and environmental risk factors.
AB - Advances in genetics and genomics during the past decade, including sequencing of the human genome and DNA sequencing technologies, have made it possible to discover the genetic basis for many diseases. With the discovery of multiple genetic loci for gastrointestinal diseases such as Crohn's disease, some have begun to wonder-Could there be a genetic basis for irritable bowel syndrome (IBS)? This article summarizes the evidence for and against a link between genes and IBS. In addition, a gene-environment paradigm is presented to combine the two opposing hypotheses, as IBS may represent a complex genetic disorder that results from the interaction of several genes and environmental risk factors.
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U2 - 10.1007/s11894-008-0069-9
DO - 10.1007/s11894-008-0069-9
M3 - Review article
C2 - 18627646
AN - SCOPUS:52049122410
SN - 1522-8037
VL - 10
SP - 355
EP - 362
JO - Current gastroenterology reports
JF - Current gastroenterology reports
IS - 4
ER -