General experimental techniques

This chapter aims to provide basic information for veterinary and investigative staff on some of the most common experimental techniques used with the laboratory rat. It contains information on handling and restraint, methods of identification, specimen collection, and substance administration and then ends with some of the more common specialized research techniques. Practical and relevant procedures and methodologies highlighted within this chapter were written to offer pertinent background information, potential refinements, and direct guidance, where feasible. This chapter does not serve as an exhaustive review of all research techniques in rats. Information regarding alternative techniques or details of procedures beyond the scope of this chapter are referenced extensively with examples from the literature.