Gene transfer for ischemic cardiovascular disease: Is this the end of the beginning or the beginning of the end?

Sorin V. Pislaru, Robert D. Simari

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

The past decade has represented a period of high expectations for cardiovascular gene transfer on the basis of the findings from preclinical experiments and promising early clinical results. Yet, randomized studies have not demonstrated similar results. Do these poor results mean that gene transfer for ischemic cardiovascular disease has failed in its promise, or do they merely signify the inherent challenges of a pioneering field? In this paper we briefly review the clinical experience of gene transfer for ischemic cardiovascular disease and propose future directions for research.

Original languageEnglish (US)
Pages (from-to)138-144
Number of pages7
JournalNature Clinical Practice Cardiovascular Medicine
Volume2
Issue number3
DOIs
StatePublished - Mar 1 2005

Keywords

  • Angiogenesis
  • Clinical trials
  • Gene therapy
  • Vectors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Gene transfer for ischemic cardiovascular disease: Is this the end of the beginning or the beginning of the end?'. Together they form a unique fingerprint.

  • Cite this