Gentherapie bei gelenkerkrankungen - Direkter eingriff in die zugrunde liegende pathophysiologie bald moglich?

Translated title of the contribution: Gene therapy of joint deseases - Direct intervention in the underlying pathophysiology soon possible?

P. Wehling, J. A. Reinecke, H. Meijer, M. Granrath, C. H. Evans

Research output: Contribution to journalArticle

Abstract

Degenerative diseases of the spinal column and joints are the most common disease in the elderly. According to surveys carried out by the National Center for Health Statistics, approximately 500 out of 1000 persons aged over 65 are affected. The corresponding numbers in Germany are probably similarly high. Although degenerative diseases of the musculoskeletal system have been intensively researched for years, we still know too little about the causes. In addition to mechanical factors, the significance of such cytokines as interleukin 1 for the development of degenerative lesions is now certain. The latest results of research work point the way to a more differentiated understanding and to innovative treatment in which, for example, the genetic code of mesenchymal cells is altered, and genetic products with anti-arthrotic and regenerative properties produced. These new strategies will have consequences not only for the treatment of degenerative diseases of the musculoskeletal system, but also for the treatment of rheumatoid arthritis.

Translated title of the contributionGene therapy of joint deseases - Direct intervention in the underlying pathophysiology soon possible?
Original languageGerman
Pages (from-to)224-227
Number of pages4
JournalKlinikarzt
Volume29
Issue number8-9
StatePublished - Oct 3 2000

Keywords

  • Cytokines
  • Degenerative diseases
  • Gene therapy
  • Genetic code

ASJC Scopus subject areas

  • Medicine(all)

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