Gentherapie in der Knorpelregeneration

The autologous chondrocyte implantation and matrix assisted autologous chondrocyte implantation are world wide accepted procedures to treat cartilage defects. Nevertheless, these methods lead to ongoing discussions due to high costs, the inconvenience of a two step procedure and partial fibrocartilage regeneration. The development of a technique using coagulated bone marrow as an autologous biological matrix to deliver growth factors by in situ gene therapy initiating cartilage repair within the defect offers the possibility of an one step procedure and to cut down the costs of ex vivo culture, transportation of cells as well as the development and production of synthetic matrices.