Gentherapie in der Knorpelregeneration

Translated title of the contribution: Gene therapy in cartilage repair

Arnulf Pascher, G. Palmer, Christopher H Evans, A. Steinert, R. Windhager, S. C. Ghivizzani

Research output: Contribution to journalArticle

Abstract

The autologous chondrocyte implantation and matrix assisted autologous chondrocyte implantation are world wide accepted procedures to treat cartilage defects. Nevertheless, these methods lead to ongoing discussions due to high costs, the inconvenience of a two step procedure and partial fibrocartilage regeneration. The development of a technique using coagulated bone marrow as an autologous biological matrix to deliver growth factors by in situ gene therapy initiating cartilage repair within the defect offers the possibility of an one step procedure and to cut down the costs of ex vivo culture, transportation of cells as well as the development and production of synthetic matrices.

Original languageGerman
Pages (from-to)74-77
Number of pages4
JournalSport-Orthopadie - Sport-Traumatologie
Volume24
Issue number2
DOIs
StatePublished - Jun 16 2008
Externally publishedYes

Fingerprint

Genetic Therapy
Cartilage
Chondrocytes
Fibrocartilage
Costs and Cost Analysis
Regeneration
Intercellular Signaling Peptides and Proteins
Cell Culture Techniques
Bone Marrow

Keywords

  • Cartilage - gene therapy - growth factors - mesenchymal stem cells - bone marrow

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Pascher, A., Palmer, G., Evans, C. H., Steinert, A., Windhager, R., & Ghivizzani, S. C. (2008). Gentherapie in der Knorpelregeneration. Sport-Orthopadie - Sport-Traumatologie, 24(2), 74-77. https://doi.org/10.1016/j.orthtr.2008.04.007

Gentherapie in der Knorpelregeneration. / Pascher, Arnulf; Palmer, G.; Evans, Christopher H; Steinert, A.; Windhager, R.; Ghivizzani, S. C.

In: Sport-Orthopadie - Sport-Traumatologie, Vol. 24, No. 2, 16.06.2008, p. 74-77.

Research output: Contribution to journalArticle

Pascher, A, Palmer, G, Evans, CH, Steinert, A, Windhager, R & Ghivizzani, SC 2008, 'Gentherapie in der Knorpelregeneration', Sport-Orthopadie - Sport-Traumatologie, vol. 24, no. 2, pp. 74-77. https://doi.org/10.1016/j.orthtr.2008.04.007
Pascher A, Palmer G, Evans CH, Steinert A, Windhager R, Ghivizzani SC. Gentherapie in der Knorpelregeneration. Sport-Orthopadie - Sport-Traumatologie. 2008 Jun 16;24(2):74-77. https://doi.org/10.1016/j.orthtr.2008.04.007
Pascher, Arnulf ; Palmer, G. ; Evans, Christopher H ; Steinert, A. ; Windhager, R. ; Ghivizzani, S. C. / Gentherapie in der Knorpelregeneration. In: Sport-Orthopadie - Sport-Traumatologie. 2008 ; Vol. 24, No. 2. pp. 74-77.
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