Gene therapy for rheumatoid arthritis.

J. N. Gouze; S. C. Ghivizzani; E. Gouze; G. D. Palmer; O. B. Betz; P. D. Robbins; C. H. Evans; J. H. Herndon

doi:10.1142/S0218810401000709

Gene therapy for rheumatoid arthritis.

J. N. Gouze, S. C. Ghivizzani, E. Gouze, G. D. Palmer, O. B. Betz, P. D. Robbins, C. H. Evans, J. H. Herndon

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Advances in understanding the biology of rheumatoid arthritis (RA) have opened new therapeutic avenues. One of these, gene therapy, involves the delivery to patients of genes encoding anti-arthritic proteins. This approach has shown efficacy in animal models of RA, and the first human, phase I trial has just been successfully completed. Hand surgery featured prominently in this pioneering study, as a potentially anti-arthritic gene encoding the interleukin-1 receptor antagonist was transferred to the metacarpophalangeal joints of subjects with RA one week before total joint arthroplasty. This study has confirmed that it is possible to transfer genes safely to human joints. It should pave the way for additional application of gene therapy to arthritis and other orthopaedic conditions.

Original language	English (US)
Pages (from-to)	211-219
Number of pages	9
Journal	Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand
Volume	6
Issue number	2
DOIs	https://doi.org/10.1142/S0218810401000709
State	Published - Dec 2001

ASJC Scopus subject areas

General Medicine

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10.1142/S0218810401000709

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Gouze, J. N., Ghivizzani, S. C., Gouze, E., Palmer, G. D., Betz, O. B., Robbins, P. D., Evans, C. H., & Herndon, J. H. (2001). Gene therapy for rheumatoid arthritis. Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand, 6(2), 211-219. https://doi.org/10.1142/S0218810401000709

Gene therapy for rheumatoid arthritis. / Gouze, J. N.; Ghivizzani, S. C.; Gouze, E. et al.
In: Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand, Vol. 6, No. 2, 12.2001, p. 211-219.

Research output: Contribution to journal › Review article › peer-review

Gouze, JN, Ghivizzani, SC, Gouze, E, Palmer, GD, Betz, OB, Robbins, PD, Evans, CH & Herndon, JH 2001, 'Gene therapy for rheumatoid arthritis.', Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand, vol. 6, no. 2, pp. 211-219. https://doi.org/10.1142/S0218810401000709

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Gene therapy for rheumatoid arthritis.

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