Gene therapy for established murine collagen-induced arthritis bylocal and systemic adenovirus-madiated delivery of interleukin-4

S. H. Kim, Christopher H Evans, S. Kim, T. Oligino, S. C. Ghivizzani, P. D. Robbins

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

To determine whether IL-4 is therapeutic in treating established experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine IL-4 (Ad-mlL-4) was used for periarticular injection into the ankle joints into mice with established collagen-induced arthritis (CIA). Periarticular injection of Ad-mlL-4 resulted in a reduction in the severity of arthritis and joint swelling compared with saline and adenoviral control groups. Local expression of IL-4 also reduced macroscopic signs of joint inflammation and bone erosion. Moreover, injection of Ad-mlL-4 into the hind ankle joints resulted in a decrease in disease severity in the untreated front paws. Systemic delivery of murine IL-4 by intravenous injection of Ad-mlL-4 resulted in a significant reduction in the severity of early-stage arthritis.

Original languageEnglish (US)
Pages (from-to)293-302
Number of pages10
JournalArthritis Research
Volume2
Issue number4
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Experimental Arthritis
Adenoviridae
Interleukin-4
Genetic Therapy
Ankle Joint
Injections
Arthritis
Joints
Osteitis
Intravenous Injections
Control Groups
Genes
Therapeutics

Keywords

  • Adenoviral vectors
  • Collagen-induced arthritis
  • Gene therapy
  • IL-10
  • IL-4
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Gene therapy for established murine collagen-induced arthritis bylocal and systemic adenovirus-madiated delivery of interleukin-4. / Kim, S. H.; Evans, Christopher H; Kim, S.; Oligino, T.; Ghivizzani, S. C.; Robbins, P. D.

In: Arthritis Research, Vol. 2, No. 4, 2000, p. 293-302.

Research output: Contribution to journalArticle

Kim, S. H. ; Evans, Christopher H ; Kim, S. ; Oligino, T. ; Ghivizzani, S. C. ; Robbins, P. D. / Gene therapy for established murine collagen-induced arthritis bylocal and systemic adenovirus-madiated delivery of interleukin-4. In: Arthritis Research. 2000 ; Vol. 2, No. 4. pp. 293-302.
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