Gene therapy for arthritis

Christopher H Evans, P. D. Robbins

Research output: Contribution to journalArticle

3 Scopus citations


In the two years since arthritis gene therapy was last reviewed in this journal, there has been rapid progress on several fronts. Although vector development remains a slow process and long-term gene expression is not easily obtained, very encouraging preclinical data in animal models of arthritis are now emerging. Collectively, these demonstrate the principle that transfer of cytokine antagonist genes to joints has a marked anti-arthritic effect. Other options under active investigation are the transfer of cytotoxic genes to effect a surgical synovectomy, and the transfer of oligonucleotides that antagonise the actions of transcription factors. Two human clinical trials of gene therapy for rheumatoid arthritis have been initiated. There are now preliminary data suggesting that gene therapy may also be helpful in osteoasthritis, as well as in the repair of cartilage, meniscus, ligaments, tendons and bones.

Original languageEnglish (US)
Pages (from-to)837-840
Number of pages4
JournalExpert Opinion on Investigational Drugs
Issue number7
StatePublished - 1997
Externally publishedYes


ASJC Scopus subject areas

  • Pharmacology

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