TY - JOUR
T1 - Gene therapy for arthritis
AU - Evans, C. H.
AU - Robbins, P. D.
N1 - Funding Information:
The authors’ work in this area is supported by NIH DK44935, AR43623 and AR62225. Mrs Lou Duerring typed the manuscript.
PY - 1997
Y1 - 1997
N2 - In the two years since arthritis gene therapy was last reviewed in this journal, there has been rapid progress on several fronts. Although vector development remains a slow process and long-term gene expression is not easily obtained, very encouraging preclinical data in animal models of arthritis are now emerging. Collectively, these demonstrate the principle that transfer of cytokine antagonist genes to joints has a marked anti-arthritic effect. Other options under active investigation are the transfer of cytotoxic genes to effect a surgical synovectomy, and the transfer of oligonucleotides that antagonise the actions of transcription factors. Two human clinical trials of gene therapy for rheumatoid arthritis have been initiated. There are now preliminary data suggesting that gene therapy may also be helpful in osteoasthritis, as well as in the repair of cartilage, meniscus, ligaments, tendons and bones.
AB - In the two years since arthritis gene therapy was last reviewed in this journal, there has been rapid progress on several fronts. Although vector development remains a slow process and long-term gene expression is not easily obtained, very encouraging preclinical data in animal models of arthritis are now emerging. Collectively, these demonstrate the principle that transfer of cytokine antagonist genes to joints has a marked anti-arthritic effect. Other options under active investigation are the transfer of cytotoxic genes to effect a surgical synovectomy, and the transfer of oligonucleotides that antagonise the actions of transcription factors. Two human clinical trials of gene therapy for rheumatoid arthritis have been initiated. There are now preliminary data suggesting that gene therapy may also be helpful in osteoasthritis, as well as in the repair of cartilage, meniscus, ligaments, tendons and bones.
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U2 - 10.1517/13543784.6.7.837
DO - 10.1517/13543784.6.7.837
M3 - Review article
C2 - 15989645
AN - SCOPUS:0030845125
SN - 1354-3784
VL - 6
SP - 837
EP - 840
JO - Expert Opinion on Investigational Drugs
JF - Expert Opinion on Investigational Drugs
IS - 7
ER -