Gene therapeutic approaches-transfer in vivo

Christopher H Evans, E. Gouze, J. N. Gouze, P. D. Robbins, S. C. Ghivizzani

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Osteoarthritis (OA) is common, debilitating, expensive, incurable and very difficult to treat. Gene transfer to the synovial linings of affected joints is a promising strategy for achieving sustained, therapeutic, intraarticular concentrations of anti-arthritic gene products. This is not reasonably possible with existing, alternative technologies. The present review summarizes progress in achieving direct, in vivo intraarticular gene delivery and expression. Numerous non-viral vectors have been evaluated for their ability to transfect the synovia of experimental animals following intraarticular injection. None have given more than low levels of temporary transgene expression and many are inflammatory. Several viral vectors, however, are very effective in this regard and successfully treat experimental models of OA. Adeno-associated virus has been used in a phase I study for the gene therapy of rheumatoid arthritis. Its use in a clinical trial for treating OA is pending.

Original languageEnglish (US)
Pages (from-to)243-258
Number of pages16
JournalAdvanced Drug Delivery Reviews
Volume58
Issue number2
DOIs
StatePublished - May 20 2006
Externally publishedYes

Fingerprint

Osteoarthritis
Genes
Intra-Articular Injections
Dependovirus
Synovial Fluid
Transgenes
Genetic Therapy
Arthritis
Rheumatoid Arthritis
Theoretical Models
Therapeutics
Joints
Clinical Trials
Technology
Gene Expression

Keywords

  • Arthritis
  • Chondrocyte
  • Gene therapy
  • Synovium
  • Virus vectors

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Evans, C. H., Gouze, E., Gouze, J. N., Robbins, P. D., & Ghivizzani, S. C. (2006). Gene therapeutic approaches-transfer in vivo. Advanced Drug Delivery Reviews, 58(2), 243-258. https://doi.org/10.1016/j.addr.2006.01.009

Gene therapeutic approaches-transfer in vivo. / Evans, Christopher H; Gouze, E.; Gouze, J. N.; Robbins, P. D.; Ghivizzani, S. C.

In: Advanced Drug Delivery Reviews, Vol. 58, No. 2, 20.05.2006, p. 243-258.

Research output: Contribution to journalArticle

Evans, CH, Gouze, E, Gouze, JN, Robbins, PD & Ghivizzani, SC 2006, 'Gene therapeutic approaches-transfer in vivo', Advanced Drug Delivery Reviews, vol. 58, no. 2, pp. 243-258. https://doi.org/10.1016/j.addr.2006.01.009
Evans, Christopher H ; Gouze, E. ; Gouze, J. N. ; Robbins, P. D. ; Ghivizzani, S. C. / Gene therapeutic approaches-transfer in vivo. In: Advanced Drug Delivery Reviews. 2006 ; Vol. 58, No. 2. pp. 243-258.
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