Gene regulatory networks that orchestrate the development of B lymphocyte precursors

Harinder Singh; Jagan M.R. Pongubala; Kay L. Medina

doi:10.1007/0-387-46530-8_5

Gene regulatory networks that orchestrate the development of B lymphocyte precursors

Harinder Singh, Jagan M.R. Pongubala, Kay L. Medina

Immunology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

25 Scopus citations

Abstract

The B cell developmental pathway represents a leading model within the hematopoietc system for the analysis of gene regulatory networks, which orchestrate cell fate specification and commitment. Considerable progress is being made in the characterization of regulatory components that comprise such networks and examining their connectivity. These components include the cytokine receptors Flk2 and IL-7R as well as the transcription factors PU.1, Ikaros, E2A, EBF and Pax-5. We review recent experimental evidence concerning the molecular functions of these regulatory components and attempt to connect them in sequentially acting and inter-dependent regulatory modules.

Original language	English (US)
Title of host publication	Mechanisms of Lymphocyte Activation and Immune Regulation XI
Subtitle of host publication	B Cell Biology
Publisher	Springer New York
Pages	57-62
Number of pages	6
ISBN (Print)	9780387465272
DOIs	https://doi.org/10.1007/0-387-46530-8_5
State	Published - 2007

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	596
ISSN (Print)	0065-2598

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/0-387-46530-8_5

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Gene regulatory networks that orchestrate the development of B lymphocyte precursors. / Singh, Harinder; Pongubala, Jagan M.R.; Medina, Kay L.

Mechanisms of Lymphocyte Activation and Immune Regulation XI: B Cell Biology. Springer New York, 2007. p. 57-62 (Advances in Experimental Medicine and Biology; Vol. 596).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AB - The B cell developmental pathway represents a leading model within the hematopoietc system for the analysis of gene regulatory networks, which orchestrate cell fate specification and commitment. Considerable progress is being made in the characterization of regulatory components that comprise such networks and examining their connectivity. These components include the cytokine receptors Flk2 and IL-7R as well as the transcription factors PU.1, Ikaros, E2A, EBF and Pax-5. We review recent experimental evidence concerning the molecular functions of these regulatory components and attempt to connect them in sequentially acting and inter-dependent regulatory modules.

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Gene regulatory networks that orchestrate the development of B lymphocyte precursors

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