Gene regulatory networks that orchestrate the development of B lymphocyte precursors

Harinder Singh, Jagan M.R. Pongubala, Kay L. Medina

Research output: Chapter in Book/Report/Conference proceedingConference contribution

25 Scopus citations


The B cell developmental pathway represents a leading model within the hematopoietc system for the analysis of gene regulatory networks, which orchestrate cell fate specification and commitment. Considerable progress is being made in the characterization of regulatory components that comprise such networks and examining their connectivity. These components include the cytokine receptors Flk2 and IL-7R as well as the transcription factors PU.1, Ikaros, E2A, EBF and Pax-5. We review recent experimental evidence concerning the molecular functions of these regulatory components and attempt to connect them in sequentially acting and inter-dependent regulatory modules.

Original languageEnglish (US)
Title of host publicationMechanisms of Lymphocyte Activation and Immune Regulation XI
Subtitle of host publicationB Cell Biology
PublisherSpringer New York
Number of pages6
ISBN (Print)9780387465272
StatePublished - 2007

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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