TY - GEN
T1 - Gene regulatory networks that orchestrate the development of B lymphocyte precursors
AU - Singh, Harinder
AU - Pongubala, Jagan M R
AU - Medina, Kay L.
PY - 2007
Y1 - 2007
N2 - The B cell developmental pathway represents a leading model within the hematopoietc system for the analysis of gene regulatory networks, which orchestrate cell fate specification and commitment. Considerable progress is being made in the characterization of regulatory components that comprise such networks and examining their connectivity. These components include the cytokine receptors Flk2 and IL-7R as well as the transcription factors PU.1, Ikaros, E2A, EBF and Pax-5. We review recent experimental evidence concerning the molecular functions of these regulatory components and attempt to connect them in sequentially acting and inter-dependent regulatory modules.
AB - The B cell developmental pathway represents a leading model within the hematopoietc system for the analysis of gene regulatory networks, which orchestrate cell fate specification and commitment. Considerable progress is being made in the characterization of regulatory components that comprise such networks and examining their connectivity. These components include the cytokine receptors Flk2 and IL-7R as well as the transcription factors PU.1, Ikaros, E2A, EBF and Pax-5. We review recent experimental evidence concerning the molecular functions of these regulatory components and attempt to connect them in sequentially acting and inter-dependent regulatory modules.
UR - http://www.scopus.com/inward/record.url?scp=34247606783&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247606783&partnerID=8YFLogxK
U2 - 10.1007/0-387-46530-8-5
DO - 10.1007/0-387-46530-8-5
M3 - Conference contribution
C2 - 17338175
SN - 9780387465272
VL - 596
T3 - Advances in Experimental Medicine and Biology
SP - 57
EP - 62
BT - Advances in Experimental Medicine and Biology
ER -