The B cell developmental pathway represents a leading system for the analysis of regulatory circuits that orchestrate cell fate specification, commitment, and differentiation. We review the progress that has been achieved in the identification and characterization of regulatory components of such circuits, including transcription factors, chromatin modifying proteins, and signaling molecules. A comprehensive developmental model is proposed that invokes sequentially acting regulatory networks which dictate the generation of B cells from multipotential hematopoietic progenitors.
|Original language||English (US)|
|Number of pages||14|
|Journal||Current Topics in Microbiology and Immunology|
|State||Published - Mar 11 2005|
ASJC Scopus subject areas
- Immunology and Allergy
- Microbiology (medical)