Gene regulatory networks orchestrating B cell fate specification, commitment and differentiation

K. L. Medina, H. Singh

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

The B cell developmental pathway represents a leading system for the analysis of regulatory circuits that orchestrate cell fate specification, commitment, and differentiation. We review the progress that has been achieved in the identification and characterization of regulatory components of such circuits, including transcription factors, chromatin modifying proteins, and signaling molecules. A comprehensive developmental model is proposed that invokes sequentially acting regulatory networks which dictate the generation of B cells from multipotential hematopoietic progenitors.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalCurrent Topics in Microbiology and Immunology
Volume290
StatePublished - Mar 11 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

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