Gene regulatory networks orchestrating B cell fate specification, commitment and differentiation

Kay L Medina, H. Singh

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The B cell developmental pathway represents a leading system for the analysis of regulatory circuits that orchestrate cell fate specification, commitment, and differentiation. We review the progress that has been achieved in the identification and characterization of regulatory components of such circuits, including transcription factors, chromatin modifying proteins, and signaling molecules. A comprehensive developmental model is proposed that invokes sequentially acting regulatory networks which dictate the generation of B cells from multipotential hematopoietic progenitors.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalCurrent Topics in Microbiology and Immunology
Volume290
StatePublished - 2005
Externally publishedYes

Fingerprint

Gene Regulatory Networks
B-Lymphocytes
Systems Analysis
Chromatin
Transcription Factors
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology and Microbiology(all)
  • Microbiology

Cite this

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