TY - JOUR
T1 - Gene regulatory networks orchestrating B cell fate specification, commitment and differentiation
AU - Medina, K. L.
AU - Singh, H.
PY - 2005
Y1 - 2005
N2 - The B cell developmental pathway represents a leading system for the analysis of regulatory circuits that orchestrate cell fate specification, commitment, and differentiation. We review the progress that has been achieved in the identification and characterization of regulatory components of such circuits, including transcription factors, chromatin modifying proteins, and signaling molecules. A comprehensive developmental model is proposed that invokes sequentially acting regulatory networks which dictate the generation of B cells from multipotential hematopoietic progenitors.
AB - The B cell developmental pathway represents a leading system for the analysis of regulatory circuits that orchestrate cell fate specification, commitment, and differentiation. We review the progress that has been achieved in the identification and characterization of regulatory components of such circuits, including transcription factors, chromatin modifying proteins, and signaling molecules. A comprehensive developmental model is proposed that invokes sequentially acting regulatory networks which dictate the generation of B cells from multipotential hematopoietic progenitors.
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U2 - 10.1007/3-540-26363-2_1
DO - 10.1007/3-540-26363-2_1
M3 - Review article
C2 - 16480036
AN - SCOPUS:14544270028
SN - 0070-217X
VL - 290
SP - 1
EP - 14
JO - Current topics in microbiology and immunology
JF - Current topics in microbiology and immunology
ER -