Gene Regulation

P. W.L. Tai, K. Kapinas, J. B. Lian, Andre J van Wijnen, J. L. Stein, G. S. Stein

Research output: Chapter in Book/Report/Conference proceedingChapter


Gene regulation is the combined biological processes that contribute to the controlled expression of genetic information. These processes can be divided into two main mechanisms: (1) transcriptional regulation, which is controlled genetically by DNA-encoded regulatory machinery and epigenetically by non-DNA-encoded mechanisms, and (2) posttranscriptional regulation, which is controlled at the level of RNA stability through the action of RNA-binding proteins and microRNAs (miRNAs).

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages5
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
StatePublished - Feb 27 2013
Externally publishedYes



  • Chromatin
  • Chromosome
  • DNA
  • Enhancer
  • Epigenetics
  • Methylation
  • MiRNA
  • MRNA
  • Nucleosome
  • Polyadenylation
  • Polymerase
  • Promoter
  • RNA
  • Transcription
  • Translation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Tai, P. W. L., Kapinas, K., Lian, J. B., van Wijnen, A. J., Stein, J. L., & Stein, G. S. (2013). Gene Regulation. In Brenner's Encyclopedia of Genetics: Second Edition (pp. 216-220). Elsevier Inc..