Gene Expression Correlates of Site-specific Metastasis Among Men With Lymph Node Positive Prostate Cancer Treated With Radical Prostatectomy: A Case Series

Vidit Sharma; Kasra Yousefi; Zaid Haddad; Christine Buerki; Robert B. Jenkins; Elai Davicioni; R. Jeffrey Karnes

doi:10.1016/j.urology.2017.10.016

Gene Expression Correlates of Site-specific Metastasis Among Men With Lymph Node Positive Prostate Cancer Treated With Radical Prostatectomy: A Case Series

Vidit Sharma, Kasra Yousefi, Zaid Haddad, Christine Buerki, Robert B. Jenkins, Elai Davicioni, R. Jeffrey Karnes

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Abstract

Predictors of site-specific metastasis after radical prostatectomy (RP) are unknown despite prognostic differences between metastatic sites. We performed RNA expression analysis for 19 genes known to be correlated with aggressive prostate cancer in primary tumors of 63 men pN+ at RP (N = 35 developing metastases after RP vs N = 28 without metastases after RP). Of the men developing metastases, 22 (62.9%) had bone metastases, 8 (22.9%) had nonregional nodal metastases, and 5(14.3%) had visceral metastases. Patients with nodal metastases had higher androgen receptor expression relative to other metastatic sites and nonmetastatic controls (P =.001). This may explain the favorable prognosis of nodal metastases as it may be more androgen dependent.

Original language	English (US)
Pages (from-to)	29-32
Number of pages	4
Journal	Urology
Volume	112
DOIs	https://doi.org/10.1016/j.urology.2017.10.016
State	Published - Feb 2018

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Urology

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Gene Expression Correlates of Site-specific Metastasis Among Men With Lymph Node Positive Prostate Cancer Treated With Radical Prostatectomy : A Case Series. / Sharma, Vidit; Yousefi, Kasra; Haddad, Zaid; Buerki, Christine; Jenkins, Robert B.; Davicioni, Elai; Karnes, R. Jeffrey.

In: Urology, Vol. 112, 02.2018, p. 29-32.

Research output: Contribution to journal › Article › peer-review

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title = "Gene Expression Correlates of Site-specific Metastasis Among Men With Lymph Node Positive Prostate Cancer Treated With Radical Prostatectomy: A Case Series",

abstract = "Predictors of site-specific metastasis after radical prostatectomy (RP) are unknown despite prognostic differences between metastatic sites. We performed RNA expression analysis for 19 genes known to be correlated with aggressive prostate cancer in primary tumors of 63 men pN+ at RP (N = 35 developing metastases after RP vs N = 28 without metastases after RP). Of the men developing metastases, 22 (62.9%) had bone metastases, 8 (22.9%) had nonregional nodal metastases, and 5(14.3%) had visceral metastases. Patients with nodal metastases had higher androgen receptor expression relative to other metastatic sites and nonmetastatic controls (P =.001). This may explain the favorable prognosis of nodal metastases as it may be more androgen dependent.",

author = "Vidit Sharma and Kasra Yousefi and Zaid Haddad and Christine Buerki and Jenkins, {Robert B.} and Elai Davicioni and Karnes, {R. Jeffrey}",

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AU - Buerki, Christine

AU - Jenkins, Robert B.

AU - Davicioni, Elai

AU - Karnes, R. Jeffrey

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N2 - Predictors of site-specific metastasis after radical prostatectomy (RP) are unknown despite prognostic differences between metastatic sites. We performed RNA expression analysis for 19 genes known to be correlated with aggressive prostate cancer in primary tumors of 63 men pN+ at RP (N = 35 developing metastases after RP vs N = 28 without metastases after RP). Of the men developing metastases, 22 (62.9%) had bone metastases, 8 (22.9%) had nonregional nodal metastases, and 5(14.3%) had visceral metastases. Patients with nodal metastases had higher androgen receptor expression relative to other metastatic sites and nonmetastatic controls (P =.001). This may explain the favorable prognosis of nodal metastases as it may be more androgen dependent.

AB - Predictors of site-specific metastasis after radical prostatectomy (RP) are unknown despite prognostic differences between metastatic sites. We performed RNA expression analysis for 19 genes known to be correlated with aggressive prostate cancer in primary tumors of 63 men pN+ at RP (N = 35 developing metastases after RP vs N = 28 without metastases after RP). Of the men developing metastases, 22 (62.9%) had bone metastases, 8 (22.9%) had nonregional nodal metastases, and 5(14.3%) had visceral metastases. Patients with nodal metastases had higher androgen receptor expression relative to other metastatic sites and nonmetastatic controls (P =.001). This may explain the favorable prognosis of nodal metastases as it may be more androgen dependent.

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Gene Expression Correlates of Site-specific Metastasis Among Men With Lymph Node Positive Prostate Cancer Treated With Radical Prostatectomy: A Case Series

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