Gene Expression Correlates of Site-specific Metastasis Among Men With Lymph Node Positive Prostate Cancer Treated With Radical Prostatectomy: A Case Series

Vidit Sharma, Kasra Yousefi, Zaid Haddad, Christine Buerki, Robert Brian Jenkins, Elai Davicioni, Robert Jeffrey Karnes

Research output: Contribution to journalArticle

Abstract

Predictors of site-specific metastasis after radical prostatectomy (RP) are unknown despite prognostic differences between metastatic sites. We performed RNA expression analysis for 19 genes known to be correlated with aggressive prostate cancer in primary tumors of 63 men pN+ at RP (N = 35 developing metastases after RP vs N = 28 without metastases after RP). Of the men developing metastases, 22 (62.9%) had bone metastases, 8 (22.9%) had nonregional nodal metastases, and 5(14.3%) had visceral metastases. Patients with nodal metastases had higher androgen receptor expression relative to other metastatic sites and nonmetastatic controls (P = .001). This may explain the favorable prognosis of nodal metastases as it may be more androgen dependent.

Original languageEnglish (US)
JournalUrology
DOIs
StateAccepted/In press - Jan 1 2017

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Prostatectomy
Prostatic Neoplasms
Lymph Nodes
Neoplasm Metastasis
Gene Expression
Androgen Receptors
Androgens
RNA
Bone and Bones

ASJC Scopus subject areas

  • Urology

Cite this

Gene Expression Correlates of Site-specific Metastasis Among Men With Lymph Node Positive Prostate Cancer Treated With Radical Prostatectomy : A Case Series. / Sharma, Vidit; Yousefi, Kasra; Haddad, Zaid; Buerki, Christine; Jenkins, Robert Brian; Davicioni, Elai; Karnes, Robert Jeffrey.

In: Urology, 01.01.2017.

Research output: Contribution to journalArticle

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abstract = "Predictors of site-specific metastasis after radical prostatectomy (RP) are unknown despite prognostic differences between metastatic sites. We performed RNA expression analysis for 19 genes known to be correlated with aggressive prostate cancer in primary tumors of 63 men pN+ at RP (N = 35 developing metastases after RP vs N = 28 without metastases after RP). Of the men developing metastases, 22 (62.9{\%}) had bone metastases, 8 (22.9{\%}) had nonregional nodal metastases, and 5(14.3{\%}) had visceral metastases. Patients with nodal metastases had higher androgen receptor expression relative to other metastatic sites and nonmetastatic controls (P = .001). This may explain the favorable prognosis of nodal metastases as it may be more androgen dependent.",
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