Abstract
Predictors of site-specific metastasis after radical prostatectomy (RP) are unknown despite prognostic differences between metastatic sites. We performed RNA expression analysis for 19 genes known to be correlated with aggressive prostate cancer in primary tumors of 63 men pN+ at RP (N = 35 developing metastases after RP vs N = 28 without metastases after RP). Of the men developing metastases, 22 (62.9%) had bone metastases, 8 (22.9%) had nonregional nodal metastases, and 5(14.3%) had visceral metastases. Patients with nodal metastases had higher androgen receptor expression relative to other metastatic sites and nonmetastatic controls (P = .001). This may explain the favorable prognosis of nodal metastases as it may be more androgen dependent.
| Original language | English (US) |
|---|---|
| Journal | Urology |
| DOIs | |
| State | Accepted/In press - Jan 1 2017 |
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ASJC Scopus subject areas
- Urology
Cite this
Gene Expression Correlates of Site-specific Metastasis Among Men With Lymph Node Positive Prostate Cancer Treated With Radical Prostatectomy : A Case Series. / Sharma, Vidit; Yousefi, Kasra; Haddad, Zaid; Buerki, Christine; Jenkins, Robert Brian; Davicioni, Elai; Karnes, Robert Jeffrey.
In: Urology, 01.01.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gene Expression Correlates of Site-specific Metastasis Among Men With Lymph Node Positive Prostate Cancer Treated With Radical Prostatectomy
T2 - A Case Series
AU - Sharma, Vidit
AU - Yousefi, Kasra
AU - Haddad, Zaid
AU - Buerki, Christine
AU - Jenkins, Robert Brian
AU - Davicioni, Elai
AU - Karnes, Robert Jeffrey
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Predictors of site-specific metastasis after radical prostatectomy (RP) are unknown despite prognostic differences between metastatic sites. We performed RNA expression analysis for 19 genes known to be correlated with aggressive prostate cancer in primary tumors of 63 men pN+ at RP (N = 35 developing metastases after RP vs N = 28 without metastases after RP). Of the men developing metastases, 22 (62.9%) had bone metastases, 8 (22.9%) had nonregional nodal metastases, and 5(14.3%) had visceral metastases. Patients with nodal metastases had higher androgen receptor expression relative to other metastatic sites and nonmetastatic controls (P = .001). This may explain the favorable prognosis of nodal metastases as it may be more androgen dependent.
AB - Predictors of site-specific metastasis after radical prostatectomy (RP) are unknown despite prognostic differences between metastatic sites. We performed RNA expression analysis for 19 genes known to be correlated with aggressive prostate cancer in primary tumors of 63 men pN+ at RP (N = 35 developing metastases after RP vs N = 28 without metastases after RP). Of the men developing metastases, 22 (62.9%) had bone metastases, 8 (22.9%) had nonregional nodal metastases, and 5(14.3%) had visceral metastases. Patients with nodal metastases had higher androgen receptor expression relative to other metastatic sites and nonmetastatic controls (P = .001). This may explain the favorable prognosis of nodal metastases as it may be more androgen dependent.
UR - http://www.scopus.com/inward/record.url?scp=85035208947&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85035208947&partnerID=8YFLogxK
U2 - 10.1016/j.urology.2017.10.016
DO - 10.1016/j.urology.2017.10.016
M3 - Article
JO - Urology
JF - Urology
SN - 0090-4295
ER -