Gene-environment interactions relevant to estrogen and risk of breast cancer: Can gene-environment interactions be detected only among candidate snps from genome-wide association studies?

Joo Yong Park; Ji Yeob Choi; Jaesung Choi; Seokang Chung; Nan Song; Sue K. Park; Wonshik Han; Dong Young Noh; Sei Hyun Ahn; Jong Won Lee; Mi Kyung Kim; Sun Ha Jee; Wanqing Wen; Manjeet K. Bolla; Qin Wang; Joe Dennis; Kyriaki Michailidou; Mitul Shah; Don M. Conroy; Patricia A. Harrington; Rebecca Mayes; Kamila Czene; Per Hall; Lauren R. Teras; Alpa V. Patel; Fergus J. Couch; Janet E. Olson; Elinor J. Sawyer; Rebecca Roylance; Stig E. Bojesen; Henrik Flyger; Diether Lambrechts; Adinda Baten; Keitaro Matsuo; Hidemi Ito; Pascal Guénel; Thérèse Truong; Renske Keeman; Marjanka K. Schmidt; Anna H. Wu; Chiu Chen Tseng; Angela Cox; Simon S. Cross; Kconfab Investigators; Irene L. Andrulis; John L. Hopper; Melissa C. Southey; Pei Ei Wu; Chen Yang Shen; Peter A. Fasching; Arif B. Ekici; Kenneth Muir; Artitaya Lophatananon; Hermann Brenner; Volker Arndt; Michael E. Jones; Anthony J. Swerdlow; Reiner Hoppe; Yon Dschun Ko; Mikael Hartman; Jingmei Li; Arto Mannermaa; Jaana M. Hartikainen; Javier Benitez; Anna González-Neira; Christopher A. Haiman; Thilo Dörk; Natalia V. Bogdanova; Soo Hwang Teo; Nur Aishah Mohd Taib; Olivia Fletcher; Nichola Johnson; Mervi Grip; Robert Winqvist; Carl Blomqvist; Heli Nevanlinna; Annika Lindblom; Camilla Wendt; Vessela N. Kristensen; N. B.C.S. Collaborators; Rob A.E.M. Tollenaar; Bernadette A.M. Heemskerk-Gerritsen; Paolo Radice; Bernardo Bonanni; Ute Hamann; Mehdi Manoochehri; James V. Lacey; Maria Elena Martinez; Alison M. Dunning; Paul D.P. Pharoah; Douglas F. Easton; Keun Young Yoo; Daehee Kang

doi:10.3390/cancers13102370

Gene-environment interactions relevant to estrogen and risk of breast cancer: Can gene-environment interactions be detected only among candidate snps from genome-wide association studies?

Joo Yong Park, Ji Yeob Choi, Jaesung Choi, Seokang Chung, Nan Song, Sue K. Park, Wonshik Han, Dong Young Noh, Sei Hyun Ahn, Jong Won Lee, Mi Kyung Kim, Sun Ha Jee, Wanqing Wen, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Mitul Shah, Don M. Conroy, Patricia A. HarringtonRebecca Mayes, Kamila Czene, Per Hall, Lauren R. Teras, Alpa V. Patel, Fergus J. Couch, Janet E. Olson, Elinor J. Sawyer, Rebecca Roylance, Stig E. Bojesen, Henrik Flyger, Diether Lambrechts, Adinda Baten, Keitaro Matsuo, Hidemi Ito, Pascal Guénel, Thérèse Truong, Renske Keeman, Marjanka K. Schmidt, Anna H. Wu, Chiu Chen Tseng, Angela Cox, Simon S. Cross, Kconfab Investigators, Irene L. Andrulis, John L. Hopper, Melissa C. Southey, Pei Ei Wu, Chen Yang Shen, Peter A. Fasching, Arif B. Ekici, Kenneth Muir, Artitaya Lophatananon, Hermann Brenner, Volker Arndt, Michael E. Jones, Anthony J. Swerdlow, Reiner Hoppe, Yon Dschun Ko, Mikael Hartman, Jingmei Li, Arto Mannermaa, Jaana M. Hartikainen, Javier Benitez, Anna González-Neira, Christopher A. Haiman, Thilo Dörk, Natalia V. Bogdanova, Soo Hwang Teo, Nur Aishah Mohd Taib, Olivia Fletcher, Nichola Johnson, Mervi Grip, Robert Winqvist, Carl Blomqvist, Heli Nevanlinna, Annika Lindblom, Camilla Wendt, Vessela N. Kristensen, N. B.C.S. Collaborators, Rob A.E.M. Tollenaar, Bernadette A.M. Heemskerk-Gerritsen, Paolo Radice, Bernardo Bonanni, Ute Hamann, Mehdi Manoochehri, James V. Lacey, Maria Elena Martinez, Alison M. Dunning, Paul D.P. Pharoah, Douglas F. Easton, Keun Young Yoo, Daehee Kang

Research output: Contribution to journal › Article › peer-review

Abstract

In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 × 10⁻³ ). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 × 10⁻⁴ ). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.

Original language	English (US)
Article number	2370
Journal	Cancers
Volume	13
Issue number	10
DOIs	https://doi.org/10.3390/cancers13102370
State	Published - May 2 2021

Keywords

Breast cancer
Estrogen
Gene-environment interaction

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3390/cancers13102370

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Park, J. Y., Choi, J. Y., Choi, J., Chung, S., Song, N., Park, S. K., Han, W., Noh, D. Y., Ahn, S. H., Lee, J. W., Kim, M. K., Jee, S. H., Wen, W., Bolla, M. K., Wang, Q., Dennis, J., Michailidou, K., Shah, M., Conroy, D. M., ... Kang, D. (2021). Gene-environment interactions relevant to estrogen and risk of breast cancer: Can gene-environment interactions be detected only among candidate snps from genome-wide association studies? Cancers, 13(10), Article 2370. https://doi.org/10.3390/cancers13102370

Park, JY, Choi, JY, Choi, J, Chung, S, Song, N, Park, SK, Han, W, Noh, DY, Ahn, SH, Lee, JW, Kim, MK, Jee, SH, Wen, W, Bolla, MK, Wang, Q, Dennis, J, Michailidou, K, Shah, M, Conroy, DM, Harrington, PA, Mayes, R, Czene, K, Hall, P, Teras, LR, Patel, AV, Couch, FJ , Olson, JE, Sawyer, EJ, Roylance, R, Bojesen, SE, Flyger, H, Lambrechts, D, Baten, A, Matsuo, K, Ito, H, Guénel, P, Truong, T, Keeman, R, Schmidt, MK, Wu, AH, Tseng, CC, Cox, A, Cross, SS, Investigators, K, Andrulis, IL, Hopper, JL, Southey, MC, Wu, PE, Shen, CY, Fasching, PA, Ekici, AB, Muir, K, Lophatananon, A, Brenner, H, Arndt, V, Jones, ME, Swerdlow, AJ, Hoppe, R, Ko, YD, Hartman, M, Li, J, Mannermaa, A, Hartikainen, JM, Benitez, J, González-Neira, A, Haiman, CA, Dörk, T, Bogdanova, NV, Teo, SH, Taib, NAM, Fletcher, O, Johnson, N, Grip, M, Winqvist, R, Blomqvist, C, Nevanlinna, H, Lindblom, A, Wendt, C, Kristensen, VN, Collaborators, NBCS, Tollenaar, RAEM, Heemskerk-Gerritsen, BAM, Radice, P, Bonanni, B, Hamann, U, Manoochehri, M, Lacey, JV, Martinez, ME, Dunning, AM, Pharoah, PDP, Easton, DF, Yoo, KY & Kang, D 2021, 'Gene-environment interactions relevant to estrogen and risk of breast cancer: Can gene-environment interactions be detected only among candidate snps from genome-wide association studies?', Cancers, vol. 13, no. 10, 2370. https://doi.org/10.3390/cancers13102370

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title = "Gene-environment interactions relevant to estrogen and risk of breast cancer: Can gene-environment interactions be detected only among candidate snps from genome-wide association studies?",

abstract = "In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 × 10−3 ). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 × 10−4 ). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.",

keywords = "Breast cancer, Estrogen, Gene-environment interaction",

author = "Park, {Joo Yong} and Choi, {Ji Yeob} and Jaesung Choi and Seokang Chung and Nan Song and Park, {Sue K.} and Wonshik Han and Noh, {Dong Young} and Ahn, {Sei Hyun} and Lee, {Jong Won} and Kim, {Mi Kyung} and Jee, {Sun Ha} and Wanqing Wen and Bolla, {Manjeet K.} and Qin Wang and Joe Dennis and Kyriaki Michailidou and Mitul Shah and Conroy, {Don M.} and Harrington, {Patricia A.} and Rebecca Mayes and Kamila Czene and Per Hall and Teras, {Lauren R.} and Patel, {Alpa V.} and Couch, {Fergus J.} and Olson, {Janet E.} and Sawyer, {Elinor J.} and Rebecca Roylance and Bojesen, {Stig E.} and Henrik Flyger and Diether Lambrechts and Adinda Baten and Keitaro Matsuo and Hidemi Ito and Pascal Gu{\'e}nel and Th{\'e}r{\`e}se Truong and Renske Keeman and Schmidt, {Marjanka K.} and Wu, {Anna H.} and Tseng, {Chiu Chen} and Angela Cox and Cross, {Simon S.} and Kconfab Investigators and Andrulis, {Irene L.} and Hopper, {John L.} and Southey, {Melissa C.} and Wu, {Pei Ei} and Shen, {Chen Yang} and Fasching, {Peter A.} and Ekici, {Arif B.} and Kenneth Muir and Artitaya Lophatananon and Hermann Brenner and Volker Arndt and Jones, {Michael E.} and Swerdlow, {Anthony J.} and Reiner Hoppe and Ko, {Yon Dschun} and Mikael Hartman and Jingmei Li and Arto Mannermaa and Hartikainen, {Jaana M.} and Javier Benitez and Anna Gonz{\'a}lez-Neira and Haiman, {Christopher A.} and Thilo D{\"o}rk and Bogdanova, {Natalia V.} and Teo, {Soo Hwang} and Taib, {Nur Aishah Mohd} and Olivia Fletcher and Nichola Johnson and Mervi Grip and Robert Winqvist and Carl Blomqvist and Heli Nevanlinna and Annika Lindblom and Camilla Wendt and Kristensen, {Vessela N.} and Collaborators, {N. B.C.S.} and Tollenaar, {Rob A.E.M.} and Heemskerk-Gerritsen, {Bernadette A.M.} and Paolo Radice and Bernardo Bonanni and Ute Hamann and Mehdi Manoochehri and Lacey, {James V.} and Martinez, {Maria Elena} and Dunning, {Alison M.} and Pharoah, {Paul D.P.} and Easton, {Douglas F.} and Yoo, {Keun Young} and Daehee Kang",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = may,

day = "2",

doi = "10.3390/cancers13102370",

language = "English (US)",

volume = "13",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "10",

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TY - JOUR

T1 - Gene-environment interactions relevant to estrogen and risk of breast cancer

T2 - Can gene-environment interactions be detected only among candidate snps from genome-wide association studies?

AU - Park, Joo Yong

AU - Choi, Ji Yeob

AU - Choi, Jaesung

AU - Chung, Seokang

AU - Song, Nan

AU - Park, Sue K.

AU - Han, Wonshik

AU - Noh, Dong Young

AU - Ahn, Sei Hyun

AU - Lee, Jong Won

AU - Kim, Mi Kyung

AU - Jee, Sun Ha

AU - Wen, Wanqing

AU - Bolla, Manjeet K.

AU - Wang, Qin

AU - Dennis, Joe

AU - Michailidou, Kyriaki

AU - Shah, Mitul

AU - Conroy, Don M.

AU - Harrington, Patricia A.

AU - Mayes, Rebecca

AU - Czene, Kamila

AU - Hall, Per

AU - Teras, Lauren R.

AU - Patel, Alpa V.

AU - Couch, Fergus J.

AU - Olson, Janet E.

AU - Sawyer, Elinor J.

AU - Roylance, Rebecca

AU - Bojesen, Stig E.

AU - Flyger, Henrik

AU - Lambrechts, Diether

AU - Baten, Adinda

AU - Matsuo, Keitaro

AU - Ito, Hidemi

AU - Guénel, Pascal

AU - Truong, Thérèse

AU - Keeman, Renske

AU - Schmidt, Marjanka K.

AU - Wu, Anna H.

AU - Tseng, Chiu Chen

AU - Cox, Angela

AU - Cross, Simon S.

AU - Investigators, Kconfab

AU - Andrulis, Irene L.

AU - Hopper, John L.

AU - Southey, Melissa C.

AU - Wu, Pei Ei

AU - Shen, Chen Yang

AU - Fasching, Peter A.

AU - Ekici, Arif B.

AU - Muir, Kenneth

AU - Lophatananon, Artitaya

AU - Brenner, Hermann

AU - Arndt, Volker

AU - Jones, Michael E.

AU - Swerdlow, Anthony J.

AU - Hoppe, Reiner

AU - Ko, Yon Dschun

AU - Hartman, Mikael

AU - Li, Jingmei

AU - Mannermaa, Arto

AU - Hartikainen, Jaana M.

AU - Benitez, Javier

AU - González-Neira, Anna

AU - Haiman, Christopher A.

AU - Dörk, Thilo

AU - Bogdanova, Natalia V.

AU - Teo, Soo Hwang

AU - Taib, Nur Aishah Mohd

AU - Fletcher, Olivia

AU - Johnson, Nichola

AU - Grip, Mervi

AU - Winqvist, Robert

AU - Blomqvist, Carl

AU - Nevanlinna, Heli

AU - Lindblom, Annika

AU - Wendt, Camilla

AU - Kristensen, Vessela N.

AU - Collaborators, N. B.C.S.

AU - Tollenaar, Rob A.E.M.

AU - Heemskerk-Gerritsen, Bernadette A.M.

AU - Radice, Paolo

AU - Bonanni, Bernardo

AU - Hamann, Ute

AU - Manoochehri, Mehdi

AU - Lacey, James V.

AU - Martinez, Maria Elena

AU - Dunning, Alison M.

AU - Pharoah, Paul D.P.

AU - Easton, Douglas F.

AU - Yoo, Keun Young

AU - Kang, Daehee

PY - 2021/5/2

Y1 - 2021/5/2

N2 - In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 × 10−3 ). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 × 10−4 ). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.

AB - In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 × 10−3 ). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 × 10−4 ). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.

KW - Breast cancer

KW - Estrogen

KW - Gene-environment interaction

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UR - http://www.scopus.com/inward/citedby.url?scp=85106038603&partnerID=8YFLogxK

U2 - 10.3390/cancers13102370

DO - 10.3390/cancers13102370

M3 - Article

AN - SCOPUS:85106038603

SN - 2072-6694

VL - 13

JO - Cancers

JF - Cancers

IS - 10

M1 - 2370

ER -

Gene-environment interactions relevant to estrogen and risk of breast cancer: Can gene-environment interactions be detected only among candidate snps from genome-wide association studies?

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