Gender-specific effects of comorbid depression and anxiety on the propensity to drink in negative emotional states

Victor M. Karpyak; Joanna M. Biernacka; Jennifer R. Geske; Osama A. Abulseoud; Michael D. Brunner; Mohit Chauhan; Daniel K. Hall-Flavin; Kriste A. Lewis; Larissa L. Loukianova; George J. Melnyk; David A. Onsrud; Brian D. Proctor; Terry D. Schneekloth; Michelle K. Skime; John E. Wittkopp; Mark A. Frye; David A. Mrazek

doi:10.1111/add.13386

Gender-specific effects of comorbid depression and anxiety on the propensity to drink in negative emotional states

Victor M. Karpyak, Joanna M. Biernacka, Jennifer R. Geske, Osama A. Abulseoud, Michael D. Brunner, Mohit Chauhan, Daniel K. Hall-Flavin, Kriste A. Lewis, Larissa L. Loukianova, George J. Melnyk, David A. Onsrud, Brian D. Proctor, Terry D. Schneekloth, Michelle K. Skime, John E. Wittkopp, Mark A. Frye, David A. Mrazek

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

BACKGROUND AND AIMS: Depression and anxiety are often comorbid with alcoholism and contribute to craving and relapse. We aimed to estimate the prevalence of life-time diagnoses of major depressive disorder (MDD), substance-induced depression (SID), anxiety disorder (AnxD) and substance-induced anxiety (SIA), the effects of these comorbidities on the propensity to drink in negative emotional states (negative craving), and test whether these effects differ by sex.

DESIGN: Secondary analyses of baseline data collected in a single-arm study of pharmacogenetic predictors of acamprosate response.

SETTING: Academic medical center and affiliated community-based treatment programs in the American upper mid-west.

PARTICIPANTS: A total of 287 males and 156 females aged 18-80 years, meeting DSM-IV criteria for alcohol dependence.

MEASUREMENTS: The primary outcome measure was 'propensity to drink in negative emotional situations' (determined by the Inventory of Drug Taking Situations) and the key predictors/covariates were sex and psychiatric comorbidities, including MDD, SID, AnxD and SIA (determined by Psychiatric Research Interview of Substance and Mood Disorders).

FINDINGS: The prevalence of the MDD, SID and AnxD was higher in females compared with males (33.1 versus 18.4%, 44.8 versus 26.4% and 42.2 versus 27.4%, respectively; P < 0.01, each), while SIA was rare (3.3%) and did not differ by sex. Increased propensity to drink in negative emotional situations was associated with comorbid MDD (β = 6.6, P = 0.013) and AnxD (β = 4.8, P = 0.042) as well as a SID × sex interaction effect (P = 0.003), indicating that the association of SID with propensity to drink in negative emotional situations differs by sex and is stronger in males (β = 7.9, P = 0.009) compared with females (β = -6.6, P = 0.091).

CONCLUSIONS: There appears to be a higher prevalence of comorbid depression and anxiety disorders as well as propensity to drink in negative emotional situations in female compared with male alcoholics. Substance-induced depression appears to have a sex-specific effect on the increased risk for drinking in negative emotional situations in males.

Original language	English (US)
Pages (from-to)	1366-1375
Number of pages	10
Journal	Addiction
Volume	111
Issue number	8
DOIs	https://doi.org/10.1111/add.13386
State	Published - Aug 1 2016

Keywords

Alcohol use disorder
anxiety
craving
depression
gender
substance-induced

ASJC Scopus subject areas

Medicine (miscellaneous)
Psychiatry and Mental health

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10.1111/add.13386

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Karpyak, V. M., Biernacka, J. M., Geske, J. R., Abulseoud, O. A., Brunner, M. D., Chauhan, M., Hall-Flavin, D. K., Lewis, K. A., Loukianova, L. L., Melnyk, G. J., Onsrud, D. A., Proctor, B. D., Schneekloth, T. D., Skime, M. K., Wittkopp, J. E., Frye, M. A., & Mrazek, D. A. (2016). Gender-specific effects of comorbid depression and anxiety on the propensity to drink in negative emotional states. Addiction, 111(8), 1366-1375. https://doi.org/10.1111/add.13386

Karpyak, VM , Biernacka, JM, Geske, JR, Abulseoud, OA, Brunner, MD, Chauhan, M, Hall-Flavin, DK, Lewis, KA, Loukianova, LL, Melnyk, GJ, Onsrud, DA, Proctor, BD, Schneekloth, TD, Skime, MK, Wittkopp, JE, Frye, MA & Mrazek, DA 2016, 'Gender-specific effects of comorbid depression and anxiety on the propensity to drink in negative emotional states', Addiction, vol. 111, no. 8, pp. 1366-1375. https://doi.org/10.1111/add.13386

@article{5f351adb7799461abce51dc036cd44e1,

title = "Gender-specific effects of comorbid depression and anxiety on the propensity to drink in negative emotional states",

abstract = "BACKGROUND AND AIMS: Depression and anxiety are often comorbid with alcoholism and contribute to craving and relapse. We aimed to estimate the prevalence of life-time diagnoses of major depressive disorder (MDD), substance-induced depression (SID), anxiety disorder (AnxD) and substance-induced anxiety (SIA), the effects of these comorbidities on the propensity to drink in negative emotional states (negative craving), and test whether these effects differ by sex.DESIGN: Secondary analyses of baseline data collected in a single-arm study of pharmacogenetic predictors of acamprosate response.SETTING: Academic medical center and affiliated community-based treatment programs in the American upper mid-west.PARTICIPANTS: A total of 287 males and 156 females aged 18-80 years, meeting DSM-IV criteria for alcohol dependence.MEASUREMENTS: The primary outcome measure was 'propensity to drink in negative emotional situations' (determined by the Inventory of Drug Taking Situations) and the key predictors/covariates were sex and psychiatric comorbidities, including MDD, SID, AnxD and SIA (determined by Psychiatric Research Interview of Substance and Mood Disorders).FINDINGS: The prevalence of the MDD, SID and AnxD was higher in females compared with males (33.1 versus 18.4%, 44.8 versus 26.4% and 42.2 versus 27.4%, respectively; P < 0.01, each), while SIA was rare (3.3%) and did not differ by sex. Increased propensity to drink in negative emotional situations was associated with comorbid MDD (β = 6.6, P = 0.013) and AnxD (β = 4.8, P = 0.042) as well as a SID × sex interaction effect (P = 0.003), indicating that the association of SID with propensity to drink in negative emotional situations differs by sex and is stronger in males (β = 7.9, P = 0.009) compared with females (β = -6.6, P = 0.091).CONCLUSIONS: There appears to be a higher prevalence of comorbid depression and anxiety disorders as well as propensity to drink in negative emotional situations in female compared with male alcoholics. Substance-induced depression appears to have a sex-specific effect on the increased risk for drinking in negative emotional situations in males.",

keywords = "Alcohol use disorder, anxiety, craving, depression, gender, substance-induced",

author = "Karpyak, {Victor M.} and Biernacka, {Joanna M.} and Geske, {Jennifer R.} and Abulseoud, {Osama A.} and Brunner, {Michael D.} and Mohit Chauhan and Hall-Flavin, {Daniel K.} and Lewis, {Kriste A.} and Loukianova, {Larissa L.} and Melnyk, {George J.} and Onsrud, {David A.} and Proctor, {Brian D.} and Schneekloth, {Terry D.} and Skime, {Michelle K.} and Wittkopp, {John E.} and Frye, {Mark A.} and Mrazek, {David A.}",

note = "Publisher Copyright: {\textcopyright} 2016 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.",

year = "2016",

month = aug,

day = "1",

doi = "10.1111/add.13386",

language = "English (US)",

volume = "111",

pages = "1366--1375",

journal = "Addiction",

issn = "0965-2140",

publisher = "Wiley-Blackwell",

number = "8",

}

TY - JOUR

T1 - Gender-specific effects of comorbid depression and anxiety on the propensity to drink in negative emotional states

AU - Karpyak, Victor M.

AU - Biernacka, Joanna M.

AU - Geske, Jennifer R.

AU - Abulseoud, Osama A.

AU - Brunner, Michael D.

AU - Chauhan, Mohit

AU - Hall-Flavin, Daniel K.

AU - Lewis, Kriste A.

AU - Loukianova, Larissa L.

AU - Melnyk, George J.

AU - Onsrud, David A.

AU - Proctor, Brian D.

AU - Schneekloth, Terry D.

AU - Skime, Michelle K.

AU - Wittkopp, John E.

AU - Frye, Mark A.

AU - Mrazek, David A.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - BACKGROUND AND AIMS: Depression and anxiety are often comorbid with alcoholism and contribute to craving and relapse. We aimed to estimate the prevalence of life-time diagnoses of major depressive disorder (MDD), substance-induced depression (SID), anxiety disorder (AnxD) and substance-induced anxiety (SIA), the effects of these comorbidities on the propensity to drink in negative emotional states (negative craving), and test whether these effects differ by sex.DESIGN: Secondary analyses of baseline data collected in a single-arm study of pharmacogenetic predictors of acamprosate response.SETTING: Academic medical center and affiliated community-based treatment programs in the American upper mid-west.PARTICIPANTS: A total of 287 males and 156 females aged 18-80 years, meeting DSM-IV criteria for alcohol dependence.MEASUREMENTS: The primary outcome measure was 'propensity to drink in negative emotional situations' (determined by the Inventory of Drug Taking Situations) and the key predictors/covariates were sex and psychiatric comorbidities, including MDD, SID, AnxD and SIA (determined by Psychiatric Research Interview of Substance and Mood Disorders).FINDINGS: The prevalence of the MDD, SID and AnxD was higher in females compared with males (33.1 versus 18.4%, 44.8 versus 26.4% and 42.2 versus 27.4%, respectively; P < 0.01, each), while SIA was rare (3.3%) and did not differ by sex. Increased propensity to drink in negative emotional situations was associated with comorbid MDD (β = 6.6, P = 0.013) and AnxD (β = 4.8, P = 0.042) as well as a SID × sex interaction effect (P = 0.003), indicating that the association of SID with propensity to drink in negative emotional situations differs by sex and is stronger in males (β = 7.9, P = 0.009) compared with females (β = -6.6, P = 0.091).CONCLUSIONS: There appears to be a higher prevalence of comorbid depression and anxiety disorders as well as propensity to drink in negative emotional situations in female compared with male alcoholics. Substance-induced depression appears to have a sex-specific effect on the increased risk for drinking in negative emotional situations in males.

AB - BACKGROUND AND AIMS: Depression and anxiety are often comorbid with alcoholism and contribute to craving and relapse. We aimed to estimate the prevalence of life-time diagnoses of major depressive disorder (MDD), substance-induced depression (SID), anxiety disorder (AnxD) and substance-induced anxiety (SIA), the effects of these comorbidities on the propensity to drink in negative emotional states (negative craving), and test whether these effects differ by sex.DESIGN: Secondary analyses of baseline data collected in a single-arm study of pharmacogenetic predictors of acamprosate response.SETTING: Academic medical center and affiliated community-based treatment programs in the American upper mid-west.PARTICIPANTS: A total of 287 males and 156 females aged 18-80 years, meeting DSM-IV criteria for alcohol dependence.MEASUREMENTS: The primary outcome measure was 'propensity to drink in negative emotional situations' (determined by the Inventory of Drug Taking Situations) and the key predictors/covariates were sex and psychiatric comorbidities, including MDD, SID, AnxD and SIA (determined by Psychiatric Research Interview of Substance and Mood Disorders).FINDINGS: The prevalence of the MDD, SID and AnxD was higher in females compared with males (33.1 versus 18.4%, 44.8 versus 26.4% and 42.2 versus 27.4%, respectively; P < 0.01, each), while SIA was rare (3.3%) and did not differ by sex. Increased propensity to drink in negative emotional situations was associated with comorbid MDD (β = 6.6, P = 0.013) and AnxD (β = 4.8, P = 0.042) as well as a SID × sex interaction effect (P = 0.003), indicating that the association of SID with propensity to drink in negative emotional situations differs by sex and is stronger in males (β = 7.9, P = 0.009) compared with females (β = -6.6, P = 0.091).CONCLUSIONS: There appears to be a higher prevalence of comorbid depression and anxiety disorders as well as propensity to drink in negative emotional situations in female compared with male alcoholics. Substance-induced depression appears to have a sex-specific effect on the increased risk for drinking in negative emotional situations in males.

KW - Alcohol use disorder

KW - anxiety

KW - craving

KW - depression

KW - gender

KW - substance-induced

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U2 - 10.1111/add.13386

DO - 10.1111/add.13386

M3 - Article

C2 - 27009547

AN - SCOPUS:85027919099

SN - 0965-2140

VL - 111

SP - 1366

EP - 1375

JO - Addiction

JF - Addiction

IS - 8

ER -

Gender-specific effects of comorbid depression and anxiety on the propensity to drink in negative emotional states

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