Gender-related differences in dyspepsia: A qualitative systematic review

Sushil K. Ahlawat, Maria Teresa Cuddihy, G. Richard Locke

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Relative to men, women are diagnosed more frequently with functional gastrointestinal (GI) disorders. With increased awareness of basic gender differences in perception and treatment of visceral pain, there has been new interest in research on gender disparity in the care of people with functional GI disorders. Past attention has focused on irritable bowel syndrome, whereas gender differences in other disorders are less well described. Objective: Our aim was to systematically review studies that have examined gender-related differences among patients with dyspepsia. Methods: MEDLINE, HealthSTAR, and PsycINFO databases were searched for English-language articles on dyspepsia published between 1966 and August 2001. Epidemiologic studies, clinical trials, review articles, and conceptual articles from peer-reviewed journals were included for review. Findings were summarized and discussed within a framework of biological and psychosocial factors. Statistical analysis of combined data was inappropriate because of the inconsistent definition of dyspepsia among different studies and wide variation in the types of articles reviewed. Results: Studies that examine gender-related differences in patients with dyspepsia have focused their investigations on the clinical epidemiology and pathophysiology of dyspepsia. In most epidemiologic studies, no gender analysis was performed beyond a description of sample demographics, and when statistical significance was tested, few consistent gender differences were found. Overall, it appears that men and women with dyspepsia possibly differ with respect to pattern of symptoms, pain perception or modulation, and antinociceptive mechanisms, but these observations have not been confirmed. No study evaluated the clinical implications of these possible differences. Conclusions: Future efforts should be directed to not only examine gender-related differences in the clinical epidemiology of dyspepsia, but also understand their clinical significance. Therefore, well-designed population-based studies using a consistent definition of dyspepsia are needed to investigate the prevalence of dyspepsia symptoms and patterns of dyspepsia management among men and women.

Original languageEnglish (US)
Pages (from-to)31-42
Number of pages12
JournalGender Medicine
Volume3
Issue number1
DOIs
StatePublished - Mar 2006

Fingerprint

Dyspepsia
gender
gender-specific factors
epidemiology
pain
biological factors
psychosocial factors
Gastrointestinal Diseases
statistical significance
statistical analysis
English language
Epidemiologic Studies
Epidemiology
Visceral Pain
Statistical Data Interpretation
Pain Perception
Irritable Bowel Syndrome
Biological Factors
management
MEDLINE

Keywords

  • dyspepsia
  • functional dyspepsia
  • gender differences

ASJC Scopus subject areas

  • Medicine(all)
  • Gender Studies

Cite this

Gender-related differences in dyspepsia : A qualitative systematic review. / Ahlawat, Sushil K.; Cuddihy, Maria Teresa; Locke, G. Richard.

In: Gender Medicine, Vol. 3, No. 1, 03.2006, p. 31-42.

Research output: Contribution to journalArticle

Ahlawat, Sushil K. ; Cuddihy, Maria Teresa ; Locke, G. Richard. / Gender-related differences in dyspepsia : A qualitative systematic review. In: Gender Medicine. 2006 ; Vol. 3, No. 1. pp. 31-42.
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