Gender-related differences in cardiac response to supine exercise assessed by radionuclide angiography

Peter C. Hanley, Alan R. Zinsmeister, Ian P. Clements, Alfred A. Bove, Manuel L. Brown, Raymond J. Gibbons

Research output: Contribution to journalArticle

66 Scopus citations


This study examines the recently reported gender differences in cardiac responses to exercise. The study group consisted of 192 men and 67 women with a low probability of coronary artery disease who underwent supine exercise radionuclide angiography. Men had a lower rest ejection fraction than that of women (0.63 versus 0.66, p = 0.02) and greater increases in ejection fraction with exercise (0.08 versus 0.02, p = 0.0001). The slope relating ejection fraction to metabolic equivalents of exercise (METs) was greater (p = 0.004) for men, even after adjustment for differences in rest ejection fraction and end-diastolic volume index. Compared with men, women had a smaller rest end-diastolic volume index (87 versus 97 ml/m2, p = 0.003) and a greater increase in end-diastolic volume index with exercise (6 versus -2 ml/m2, p = 0.002). The slope relating end-diastolic volume to METs was greater for women, even after adjustment for differences in rest end-diastolic volume index and peak work load. There are clear gender differences in the supine exercise response of ejection fraction and end-diastolic volume that are not explained by differences in exercise capacity.

Original languageEnglish (US)
Pages (from-to)624-629
Number of pages6
JournalJournal of the American College of Cardiology
Issue number3
StatePublished - Mar 1 1989


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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