Gender differences in C-reactive protein concentration - Confirmation with two sensitive methods

Joseph P. McConnell, Earl L. Branum, Karla V. Ballman, Susan A. Lagerstedt, Jerry A. Katzmann, Allan S Jaffe

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Two new automated, highly sensitive methods for the measurement of C-reactive protein (CRP) were compared using blood samples from active and retired health care workers (116 males, 114 females). The regression equation was y = 1.115x-0.0267 for the Kamiya K assay immunoturbidimetric method (x) vs. the Behring BNII nephelometric method (y) with medians (IQR) of 0.156 (0.081 to 0.276) and 0.150 (0.060 to 0.240) mg/dl, respectively. Significant differences in hsCRP values between males and females were observed (p = 0.013 and p = 0.0018 for Behring and Kamiya methods, respectively). This gender difference in CRP levels was confirmed by analysis of serum samples from 1114 individuals (639 males and 475 females) obtained through Mayo Medical Laboratories reference services, which represents participants from across the United States. The gender difference, which was confirmed (p < 0.0001), was independent of age differences as assessed by multiple regression analysis. The observed gender differences have important implications for the establishment of cut-off points for cardiovascular risk stratification.

Original languageEnglish (US)
Pages (from-to)56-59
Number of pages4
JournalClinical Chemistry and Laboratory Medicine
Volume40
Issue number1
DOIs
StatePublished - 2002

Fingerprint

C-Reactive Protein
Health care
Regression analysis
Assays
Blood
Regression Analysis
Delivery of Health Care
Serum

Keywords

  • Gender differences
  • High sensitivity C-reactive protein
  • Method comparison

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Gender differences in C-reactive protein concentration - Confirmation with two sensitive methods. / McConnell, Joseph P.; Branum, Earl L.; Ballman, Karla V.; Lagerstedt, Susan A.; Katzmann, Jerry A.; Jaffe, Allan S.

In: Clinical Chemistry and Laboratory Medicine, Vol. 40, No. 1, 2002, p. 56-59.

Research output: Contribution to journalArticle

McConnell, Joseph P. ; Branum, Earl L. ; Ballman, Karla V. ; Lagerstedt, Susan A. ; Katzmann, Jerry A. ; Jaffe, Allan S. / Gender differences in C-reactive protein concentration - Confirmation with two sensitive methods. In: Clinical Chemistry and Laboratory Medicine. 2002 ; Vol. 40, No. 1. pp. 56-59.
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