Gender-based analysis of esophageal cancer patients undergoing preoperative chemoradiation: Differences in presentation and therapy outcome

P. R. Rohatgi, A. M. Correa, S. G. Swisher, T. T. Wu, Z. Liao, R. Komaki, G. L. Walsh, A. A. Vaporciyan, J. H. Lee, D. C. Rice, J. A. Roth, J. A. Ajani

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The purpose of this study was to identify gender-dependent differences in presentation at baseline and therapy outcome in esophageal carcinoma patients treated with preoperative chemoradiotherapy (CTRT). We stratified patients according to gender and statistically compared pretreatment clinical stage, post-CTRT effect on carcinoma in the resected specimen, overall survival (OS), and patterns of failure. Of the 235 patients who underwent preoperative CTRT, 203 were men and 32 were women. Carcinomas in women correlated significantly with clinical stage II classification (78% vs. 55%) while cancers in men correlated significantly with clinical stage III classification (39% vs. 16%; P = 0.02). Carcinomas in women also correlated significantly with lower clinical N classification; more women had cN0 (52%) compared to men (28%; P = 0.01). Similarly, in the surgical specimens, more women had pN0 (78%) compared to men (64%; P = 0.06). At a median follow-up of 37 months, 10% more women than men remain alive (63% vs. 535; P = 0.3). Distant metastases-free survival time was longer for women than men. Our results suggest that localized esophageal carcinoma is diagnosed in more advanced stages in men than in women. The reasons for these differences remain unclear and further expansion of these observations and study of biologic differences that might exist are warranted.

Original languageEnglish (US)
Pages (from-to)152-157
Number of pages6
JournalDiseases of the Esophagus
Volume19
Issue number3
DOIs
StatePublished - Jun 2006
Externally publishedYes

Fingerprint

Esophageal Neoplasms
Carcinoma
Therapeutics
Survival
Chemoradiotherapy
Neoplasm Metastasis
Neoplasms

Keywords

  • Esophageal cancer
  • Gender
  • Outcome
  • Preoperative chemoradiation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Gender-based analysis of esophageal cancer patients undergoing preoperative chemoradiation : Differences in presentation and therapy outcome. / Rohatgi, P. R.; Correa, A. M.; Swisher, S. G.; Wu, T. T.; Liao, Z.; Komaki, R.; Walsh, G. L.; Vaporciyan, A. A.; Lee, J. H.; Rice, D. C.; Roth, J. A.; Ajani, J. A.

In: Diseases of the Esophagus, Vol. 19, No. 3, 06.2006, p. 152-157.

Research output: Contribution to journalArticle

Rohatgi, PR, Correa, AM, Swisher, SG, Wu, TT, Liao, Z, Komaki, R, Walsh, GL, Vaporciyan, AA, Lee, JH, Rice, DC, Roth, JA & Ajani, JA 2006, 'Gender-based analysis of esophageal cancer patients undergoing preoperative chemoradiation: Differences in presentation and therapy outcome', Diseases of the Esophagus, vol. 19, no. 3, pp. 152-157. https://doi.org/10.1111/j.1442-2050.2006.00557.x
Rohatgi, P. R. ; Correa, A. M. ; Swisher, S. G. ; Wu, T. T. ; Liao, Z. ; Komaki, R. ; Walsh, G. L. ; Vaporciyan, A. A. ; Lee, J. H. ; Rice, D. C. ; Roth, J. A. ; Ajani, J. A. / Gender-based analysis of esophageal cancer patients undergoing preoperative chemoradiation : Differences in presentation and therapy outcome. In: Diseases of the Esophagus. 2006 ; Vol. 19, No. 3. pp. 152-157.
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