Gender and vascular reactivity

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Estrogen receptors are found on vascular endothelial and smooth muscle cells; their expression is influenced by exposure to the hormone. Estrogen receptors influence non-genomic events, which are rapid in onset and genomic events, which are longer acting responses. Estrogens affect vascular tone indirectly by modulating release of endothelium-derived vasoactive factors and directly by modulating intracellular calcium in vascular smooth muscle cells. Estrogens indirecrty affect thrombotic events and inflammation by altering platelet aggregation and leukocyte adherence and migration, respectively. Estrogens also influence production of mitogens which, when released at sites of vascular injury, affect vascular remodeling. Although estrogens initiate vascular responses, genomic sex may influence and/or limit expression of estrogen receptors and therefore actions of sex steroid hormones throughout the vasculature.

Original languageEnglish (US)
Pages (from-to)409-415
Number of pages7
JournalLupus
Volume8
Issue number5
StatePublished - 1999

Fingerprint

Blood Vessels
Estrogens
Estrogen Receptors
Vascular Smooth Muscle
Smooth Muscle Myocytes
Vascular System Injuries
Gonadal Steroid Hormones
Platelet Aggregation
Mitogens
Endothelium
Leukocytes
Hormones
Inflammation
Calcium

Keywords

  • Coronary artery disease
  • Endothelin-I
  • Endothelium
  • Estrogen
  • Nitric oxide
  • Vascular smooth muscle
  • X chromosome
  • Y chromosome

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Gender and vascular reactivity. / Miller, Virginia M.

In: Lupus, Vol. 8, No. 5, 1999, p. 409-415.

Research output: Contribution to journalArticle

Miller, VM 1999, 'Gender and vascular reactivity', Lupus, vol. 8, no. 5, pp. 409-415.
Miller, Virginia M. / Gender and vascular reactivity. In: Lupus. 1999 ; Vol. 8, No. 5. pp. 409-415.
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