Gender and pramipexole effects on levodopa pharmacokinetics and pharmacodynamics

Katie Kompoliti, C. H. Adler, R. Raman, J. H. Pincus, M. T. Leibowitz, J. J. Ferry, L. Blasucci, J. N. Caviness, S. Leurgans, W. M. Chase, L. C. Yones, E. Tan, P. Carvey, C. G. Goetz

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The authors studied the pharmacokinetics of levodopa (LD) with and without pramipexole (PPX) in men and postmenopausal women with PD. Patients on stable dose of carbidopa/LD were randomized to receive escalating doses of placebo or PPX over 7 weeks. LD and PPX pharmacokinetics were performed after a single test dose 25/100 of carbidopa/LD, before initiation of PPX or placebo, at 1.5 mg/d and 4.5 mg/d of PPX or placebo. Compared to men, women had greater LD bioavailability. PPX did not alter LD bioavailability, and PPX pharmacokinetics were equivalent in men and women.

Original languageEnglish (US)
Pages (from-to)1418-1422
Number of pages5
JournalNeurology
Volume58
Issue number9
DOIs
StatePublished - May 14 2002

ASJC Scopus subject areas

  • Clinical Neurology

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    Kompoliti, K., Adler, C. H., Raman, R., Pincus, J. H., Leibowitz, M. T., Ferry, J. J., Blasucci, L., Caviness, J. N., Leurgans, S., Chase, W. M., Yones, L. C., Tan, E., Carvey, P., & Goetz, C. G. (2002). Gender and pramipexole effects on levodopa pharmacokinetics and pharmacodynamics. Neurology, 58(9), 1418-1422. https://doi.org/10.1212/WNL.58.9.1418