Gastroparesis

Michael Camilleri, Victor Chedid, Alexander C. Ford, Ken Haruma, Michael Horowitz, Karen L. Jones, Phillip Anson Low, Seon Young Park, Henry P. Parkman, Vincenzo Stanghellini

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Gastroparesis is a disorder characterized by delayed gastric emptying of solid food in the absence of a mechanical obstruction of the stomach, resulting in the cardinal symptoms of early satiety, postprandial fullness, nausea, vomiting, belching and bloating. Gastroparesis is now recognized as part of a broader spectrum of gastric neuromuscular dysfunction that includes impaired gastric accommodation. The overlap between upper gastrointestinal symptoms makes the distinction between gastroparesis and other disorders, such as functional dyspepsia, challenging. Thus, a confirmed diagnosis of gastroparesis requires measurement of delayed gastric emptying via an appropriate test, such as gastric scintigraphy or breath testing. Gastroparesis can have idiopathic, diabetic, iatrogenic, post-surgical or post-viral aetiologies. The management of gastroparesis involves: correcting fluid, electrolyte and nutritional deficiencies; identifying and treating the cause of delayed gastric emptying (for example, diabetes mellitus); and suppressing or eliminating symptoms with pharmacological agents as first-line therapies. Several novel pharmacologic agents and interventions are currently in the pipeline and show promise to help tailor individualized therapy for patients with gastroparesis.

Original languageEnglish (US)
Number of pages1
JournalNature reviews. Disease primers
Volume4
Issue number1
DOIs
StatePublished - Nov 1 2018

Fingerprint

Gastroparesis
Gastric Emptying
Stomach
Eructation
Dyspepsia
Malnutrition
Radionuclide Imaging
Nausea
Electrolytes
Vomiting
Diabetes Mellitus
Pharmacology
Food
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Camilleri, M., Chedid, V., Ford, A. C., Haruma, K., Horowitz, M., Jones, K. L., ... Stanghellini, V. (2018). Gastroparesis. Nature reviews. Disease primers, 4(1). https://doi.org/10.1038/s41572-018-0038-z

Gastroparesis. / Camilleri, Michael; Chedid, Victor; Ford, Alexander C.; Haruma, Ken; Horowitz, Michael; Jones, Karen L.; Low, Phillip Anson; Park, Seon Young; Parkman, Henry P.; Stanghellini, Vincenzo.

In: Nature reviews. Disease primers, Vol. 4, No. 1, 01.11.2018.

Research output: Contribution to journalReview article

Camilleri, M, Chedid, V, Ford, AC, Haruma, K, Horowitz, M, Jones, KL, Low, PA, Park, SY, Parkman, HP & Stanghellini, V 2018, 'Gastroparesis', Nature reviews. Disease primers, vol. 4, no. 1. https://doi.org/10.1038/s41572-018-0038-z
Camilleri M, Chedid V, Ford AC, Haruma K, Horowitz M, Jones KL et al. Gastroparesis. Nature reviews. Disease primers. 2018 Nov 1;4(1). https://doi.org/10.1038/s41572-018-0038-z
Camilleri, Michael ; Chedid, Victor ; Ford, Alexander C. ; Haruma, Ken ; Horowitz, Michael ; Jones, Karen L. ; Low, Phillip Anson ; Park, Seon Young ; Parkman, Henry P. ; Stanghellini, Vincenzo. / Gastroparesis. In: Nature reviews. Disease primers. 2018 ; Vol. 4, No. 1.
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