Abstract
The term gastrointestinal neuromuscular disease describes a clinically heterogeneous group of disorders of children and adults in which symptoms are presumed or proven to arise as a result of neuromuscular, including interstitial cell of Cajal, dysfunction. Such disorders commonly have impaired motor activity, i.e. slowed or obstructed transit with radiological evidence of transient or persistent visceral dilatation. Whilst sensorimotor abnormalities have been demonstrated by a variety of methods in these conditions, standards for histopathological reporting remain relatively neglected. Significant differences in methodologies and expertise continue to confound the reliable delineation of normality and specificity of particular pathological changes for disease. Such issues require urgent clarification to standardize acquisition and handling of tissue specimens, interpretation of findings and make informed decisions on risk-benefit of full-thickness tissue biopsy of bowel or other diagnostic procedures. Such information will also allow increased certainty of diagnosis, facilitating factual discussion between patients and caregivers, as well as giving prognostic and therapeutic information. The following report, produced by an international working group, using established consensus methodology, presents proposed guidelines on histological techniques and reporting for adult and paediatric gastrointestinal neuromuscular pathology. The report addresses the main areas of histopathological practice as confronted by the pathologist, including suction rectal biopsy and full-thickness tissue obtained with diagnostic or therapeutic intent. For each, indications, safe acquisition of tissue, histological techniques, reporting and referral recommendations are presented.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 271-301 |
| Number of pages | 31 |
| Journal | Acta Neuropathologica |
| Volume | 118 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2009 |
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Keywords
- Enteric myopathy
- Enteric neuropathy
- Hirschsprung disease
- Histopathology
- Interstitial cells of Cajal
- Intestinal pseudo-obstruction
- Suction rectal biopsy
ASJC Scopus subject areas
- Clinical Neurology
- Pathology and Forensic Medicine
- Cellular and Molecular Neuroscience
Cite this
Gastrointestinal neuromuscular pathology : Guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group. / Knowles, Charles H.; De Giorgio, Roberto; Kapur, Raj P.; Bruder, Elisabeth; Farrugia, Gianrico; Geboes, Karel; Gershon, Michael D.; Hutson, John; Lindberg, Greger; Martin, Joanne E.; Meier-Ruge, William A.; Milla, Peter J.; Smith, Virpi V.; Vandervinden, Jean Marie; Veress, Béla; Wedel, Thilo.
In: Acta Neuropathologica, Vol. 118, No. 2, 2009, p. 271-301.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gastrointestinal neuromuscular pathology
T2 - Guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group
AU - Knowles, Charles H.
AU - De Giorgio, Roberto
AU - Kapur, Raj P.
AU - Bruder, Elisabeth
AU - Farrugia, Gianrico
AU - Geboes, Karel
AU - Gershon, Michael D.
AU - Hutson, John
AU - Lindberg, Greger
AU - Martin, Joanne E.
AU - Meier-Ruge, William A.
AU - Milla, Peter J.
AU - Smith, Virpi V.
AU - Vandervinden, Jean Marie
AU - Veress, Béla
AU - Wedel, Thilo
PY - 2009
Y1 - 2009
N2 - The term gastrointestinal neuromuscular disease describes a clinically heterogeneous group of disorders of children and adults in which symptoms are presumed or proven to arise as a result of neuromuscular, including interstitial cell of Cajal, dysfunction. Such disorders commonly have impaired motor activity, i.e. slowed or obstructed transit with radiological evidence of transient or persistent visceral dilatation. Whilst sensorimotor abnormalities have been demonstrated by a variety of methods in these conditions, standards for histopathological reporting remain relatively neglected. Significant differences in methodologies and expertise continue to confound the reliable delineation of normality and specificity of particular pathological changes for disease. Such issues require urgent clarification to standardize acquisition and handling of tissue specimens, interpretation of findings and make informed decisions on risk-benefit of full-thickness tissue biopsy of bowel or other diagnostic procedures. Such information will also allow increased certainty of diagnosis, facilitating factual discussion between patients and caregivers, as well as giving prognostic and therapeutic information. The following report, produced by an international working group, using established consensus methodology, presents proposed guidelines on histological techniques and reporting for adult and paediatric gastrointestinal neuromuscular pathology. The report addresses the main areas of histopathological practice as confronted by the pathologist, including suction rectal biopsy and full-thickness tissue obtained with diagnostic or therapeutic intent. For each, indications, safe acquisition of tissue, histological techniques, reporting and referral recommendations are presented.
AB - The term gastrointestinal neuromuscular disease describes a clinically heterogeneous group of disorders of children and adults in which symptoms are presumed or proven to arise as a result of neuromuscular, including interstitial cell of Cajal, dysfunction. Such disorders commonly have impaired motor activity, i.e. slowed or obstructed transit with radiological evidence of transient or persistent visceral dilatation. Whilst sensorimotor abnormalities have been demonstrated by a variety of methods in these conditions, standards for histopathological reporting remain relatively neglected. Significant differences in methodologies and expertise continue to confound the reliable delineation of normality and specificity of particular pathological changes for disease. Such issues require urgent clarification to standardize acquisition and handling of tissue specimens, interpretation of findings and make informed decisions on risk-benefit of full-thickness tissue biopsy of bowel or other diagnostic procedures. Such information will also allow increased certainty of diagnosis, facilitating factual discussion between patients and caregivers, as well as giving prognostic and therapeutic information. The following report, produced by an international working group, using established consensus methodology, presents proposed guidelines on histological techniques and reporting for adult and paediatric gastrointestinal neuromuscular pathology. The report addresses the main areas of histopathological practice as confronted by the pathologist, including suction rectal biopsy and full-thickness tissue obtained with diagnostic or therapeutic intent. For each, indications, safe acquisition of tissue, histological techniques, reporting and referral recommendations are presented.
KW - Enteric myopathy
KW - Enteric neuropathy
KW - Hirschsprung disease
KW - Histopathology
KW - Interstitial cells of Cajal
KW - Intestinal pseudo-obstruction
KW - Suction rectal biopsy
UR - http://www.scopus.com/inward/record.url?scp=67650671504&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650671504&partnerID=8YFLogxK
U2 - 10.1007/s00401-009-0527-y
DO - 10.1007/s00401-009-0527-y
M3 - Article
C2 - 19360428
AN - SCOPUS:67650671504
VL - 118
SP - 271
EP - 301
JO - Acta Neuropathologica
JF - Acta Neuropathologica
SN - 0001-6322
IS - 2
ER -