Gastrointestinal motility disturbances in patients with orthostatic hypotension

Michael Camilleri, Juan R. Malagelada, Vincenzo Stanghellini, Robert D. Fealey, Sheldon G. Sheps

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Orthostatic hypotension syndromes may be associated with visceral denervation, resulting in disturbances of the gastrointestinal and urinary systems. This report analyzes the findings in 9 patients with neurogenic orthostatic hypotension and gastrointestinal symptoms. Antral and proximal small intestinal motor dysfunction was demonstrated in all patients: a significant reduction (p = 0.007) in the number of interdigestive motor complexes during 3 h of fasting (mean 0.4 vs. 1.3 controls); absence of gastric component in interdigestive motor complexes observed; incoordination of fasting and fed antral activity; and development of nonpropagating bursts of phase III-like activity in the intestine that were of at least 2-min duration, high amplitude and frequency, and associated with tonic elevations in baseline pressure. These motor abnormalities may provide a potential means for the diagnosis of impaired autonomic supply to the upper gut.

Original languageEnglish (US)
Pages (from-to)1852-1859
Number of pages8
JournalGastroenterology
Volume88
Issue number6
DOIs
StatePublished - Jun 1985

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Gastrointestinal motility disturbances in patients with orthostatic hypotension'. Together they form a unique fingerprint.

  • Cite this