Gastrointestinal lymphoma

Nick Rooney, A. Dogan

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Gastrointestinal lymphoma occurs in many forms, some characteristic of their location. The most common form is extranodal marginal zone lymphoma of MALT type, usually abbreviated to MALT lymphoma. This entity recreates the structure and cytological features of normal mucosa-associated lymphoid tissues. In the stomach this is associated with infection by Helicobacter pylori. Three translocations are implicated in the development of MALT lymphoma, t(1;14), t(11;18) and t(14;18). These interfere with the normal pathways of Bcl-10 and MALT-1. Enteropathy-type intestinal T-cell lymphoma represents one end of a spectrum of disorders including refractory sprue and ulcerative jejunitis characterized by a proliferation of phenotypically abnormal mucosal T-cell clones. Some cases arise as a complication of long-standing coeliac disease but most present in adulthood. A history of nutritional problems and loose stools may indicate refractory coeliac disease.

Original languageEnglish (US)
Pages (from-to)69-78
Number of pages10
JournalCurrent Diagnostic Pathology
Volume10
Issue number1
DOIs
StatePublished - Feb 2004
Externally publishedYes

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Keywords

  • Chromosomal translocation
  • Coeliac disease
  • Gastrointestinal neoplasms
  • Lymphoma, mucosa-associated lymphoid tissue
  • Lymphoma, T-cell
  • Oncogene proteins, fusion

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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