Gastrointestinal involvement in paroxysmal nocturnal hemoglobinuria: First report of electron microscopic findings

T. Adams, David E. Fleischer, G. Marino, E. Rusnock, L. Li

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Thrombotic complications, particularly microthrombi involving intraabdominal veins leading to intestinal ischemia, have remained a major cause of morbidity in patients with paroxysmal nocturnal hemoglobinuria (PNH). While intestinal ischemia has been postulated to be the cause of recurrent bouts of abdominal pain in this population, direct antemortem evidence for this complication is scarcely documented in the literature. We describe a case of PNH in a patient who presented with abdominal distress three years after the initial diagnosis was established. Clinical features and a combination of diagnostic modalities, including radiography, endoscopy, and histology were used to make the prompt diagnosis of intestinal ischemia. This is the first case in which the electronic microscopy of the gastrointestinal lesion is described. Our patient was successfully treated with conservative measures and anticoagulation.

Original languageEnglish (US)
Article number366413
Pages (from-to)58-64
Number of pages7
JournalDigestive diseases and sciences
Volume47
Issue number1
DOIs
StatePublished - Jan 1 2002

Keywords

  • Electron microscopy
  • Intestinal ischemia
  • Paroxysmal nocturnal hemoglobinuria

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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