Gastrointestinal Function

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter discusses various functions of the gastrointestinal tract that is essential for the orderly digestion, absorption, and transportation of food and residue. The motor activity of the gut is one of the integrated functions that are essential for the normal assimilation of food. Gut motility facilitates the transportation of nutrients, brings together digestive enzymes and their substrates, temporarily stores content, particularly in the distal small bowel and right colon, for optimal absorption, and finally, excretes nondigestible residue by defecation in a well-coordinated function under voluntary control. The extrinsic autonomic nervous system (ANS) is critically important for almost all secretory and motor functions in the digestive tract. The function of the gastrointestinal smooth muscle is intimately controlled by the release of peptides and transmitters by the intrinsic (or enteric) nervous system; the modulation of the latter input arises in the extrinsic autonomic nerves, the craniospinal parasympathetic excitatory input, and the thoracolumbar sympathetic outflow, which is predominantly inhibitory to the gut but excitatory to the sphincter. Gastrointestinal smooth muscle forms an electrical syncytium whereby the impulse that induces the contraction of the first muscle cell results in efficient transmission to a sheet of sequentially linked cells in the transverse and longitudinal axes of the intestine. The pacemaker of the intestinal muscle syncytium is the network of interstitial cells of Cajal that serve to coordinate contraction circumferentially and longitudinally along the gut.

Original languageEnglish (US)
Title of host publicationPrimer on the Autonomic Nervous System: Second Edition
PublisherElsevier Inc.
Pages118-121
Number of pages4
ISBN (Print)9780080473963, 9780125897624
DOIs
StatePublished - May 5 2004

Fingerprint

Giant Cells
Food
Smooth Muscle
Gastrointestinal Tract
Interstitial Cells of Cajal
Enteric Nervous System
Autonomic Pathways
Defecation
Autonomic Nervous System
Muscle Cells
Intestines
Digestion
Colon
Motor Activity
Muscles
Peptides
Enzymes

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Camilleri, M. (2004). Gastrointestinal Function. In Primer on the Autonomic Nervous System: Second Edition (pp. 118-121). Elsevier Inc.. https://doi.org/10.1016/B978-012589762-4/50030-X

Gastrointestinal Function. / Camilleri, Michael.

Primer on the Autonomic Nervous System: Second Edition. Elsevier Inc., 2004. p. 118-121.

Research output: Chapter in Book/Report/Conference proceedingChapter

Camilleri, M 2004, Gastrointestinal Function. in Primer on the Autonomic Nervous System: Second Edition. Elsevier Inc., pp. 118-121. https://doi.org/10.1016/B978-012589762-4/50030-X
Camilleri M. Gastrointestinal Function. In Primer on the Autonomic Nervous System: Second Edition. Elsevier Inc. 2004. p. 118-121 https://doi.org/10.1016/B978-012589762-4/50030-X
Camilleri, Michael. / Gastrointestinal Function. Primer on the Autonomic Nervous System: Second Edition. Elsevier Inc., 2004. pp. 118-121
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