Abstract
We describe the histopathologic features of 6 cases of gastrointestinal basidiobolomycosis examined at 4 Phoenix, AZ, area hospitals during the last 4 years. Resected stomach and intestinal specimens were characterized by marked mural thickening with fibrosis, prominent tissue eosinophil infiltration and palisading granulomatous inflammation around pate fungal hyphae. In 2 cases, there was colonic perforation. Basidiobolus ranarum hyphae (associated with spore-like spherules in 4 cases) were identified within tissue sections; the irregularly branched, thin-walled, occasionally septated hyphae were typically surrounded by a thick eosinophilic cuff (Splendore-Hoeppli phenomenon). Although the histologic features of B ranarum are well described in the skin and subcutaneous tissue, gastrointestinal involvement has presented considerable diagnostic difficulty. Before the occurrence of this cluster of cases, intra-abdominal B ranarum infection has been reported only rarely.
Original language | English (US) |
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Pages (from-to) | 610-616 |
Number of pages | 7 |
Journal | American journal of clinical pathology |
Volume | 112 |
Issue number | 5 |
DOIs | |
State | Published - 1999 |
Keywords
- Basidiobolus
- Eosinophils
- Gastrointestinal
- Granuloma
- Hyalohyphomycosis
- Mycosis
- Splendore- Hoeppli
- Zygomycosis
ASJC Scopus subject areas
- Pathology and Forensic Medicine