Gastrointestinal basidiobolomycosis

Morphologic findings in a cluster of six cases

Omar M. Yousef, Jerry D. Smilack, David M. Kerr, Robert Ramsey, Louis Rosati, Thomas V. Colby

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

We describe the histopathologic features of 6 cases of gastrointestinal basidiobolomycosis examined at 4 Phoenix, AZ, area hospitals during the last 4 years. Resected stomach and intestinal specimens were characterized by marked mural thickening with fibrosis, prominent tissue eosinophil infiltration and palisading granulomatous inflammation around pate fungal hyphae. In 2 cases, there was colonic perforation. Basidiobolus ranarum hyphae (associated with spore-like spherules in 4 cases) were identified within tissue sections; the irregularly branched, thin-walled, occasionally septated hyphae were typically surrounded by a thick eosinophilic cuff (Splendore-Hoeppli phenomenon). Although the histologic features of B ranarum are well described in the skin and subcutaneous tissue, gastrointestinal involvement has presented considerable diagnostic difficulty. Before the occurrence of this cluster of cases, intra-abdominal B ranarum infection has been reported only rarely.

Original languageEnglish (US)
Pages (from-to)610-616
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume112
Issue number5
StatePublished - 1999

Fingerprint

Hyphae
Entomophthorales
Subcutaneous Tissue
Spores
Eosinophils
Stomach
Fibrosis
Inflammation
Skin
Infection

Keywords

  • Basidiobolus
  • Eosinophils
  • Gastrointestinal
  • Granuloma
  • Hyalohyphomycosis
  • Mycosis
  • Splendore- Hoeppli
  • Zygomycosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Yousef, O. M., Smilack, J. D., Kerr, D. M., Ramsey, R., Rosati, L., & Colby, T. V. (1999). Gastrointestinal basidiobolomycosis: Morphologic findings in a cluster of six cases. American Journal of Clinical Pathology, 112(5), 610-616.

Gastrointestinal basidiobolomycosis : Morphologic findings in a cluster of six cases. / Yousef, Omar M.; Smilack, Jerry D.; Kerr, David M.; Ramsey, Robert; Rosati, Louis; Colby, Thomas V.

In: American Journal of Clinical Pathology, Vol. 112, No. 5, 1999, p. 610-616.

Research output: Contribution to journalArticle

Yousef, OM, Smilack, JD, Kerr, DM, Ramsey, R, Rosati, L & Colby, TV 1999, 'Gastrointestinal basidiobolomycosis: Morphologic findings in a cluster of six cases', American Journal of Clinical Pathology, vol. 112, no. 5, pp. 610-616.
Yousef OM, Smilack JD, Kerr DM, Ramsey R, Rosati L, Colby TV. Gastrointestinal basidiobolomycosis: Morphologic findings in a cluster of six cases. American Journal of Clinical Pathology. 1999;112(5):610-616.
Yousef, Omar M. ; Smilack, Jerry D. ; Kerr, David M. ; Ramsey, Robert ; Rosati, Louis ; Colby, Thomas V. / Gastrointestinal basidiobolomycosis : Morphologic findings in a cluster of six cases. In: American Journal of Clinical Pathology. 1999 ; Vol. 112, No. 5. pp. 610-616.
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