Gastroesophageal reflux therapy is associated with longer survival in patients with idiopathic pulmonary fibrosis

Joyce S. Lee, Jay H. Ryu, Brett M. Elicker, Carmen P. Lydell, Kirk D. Jones, Paul J. Wolters, Talmadge E. King, Harold R. Collard

Research output: Contribution to journalArticlepeer-review

271 Scopus citations

Abstract

Rationale: Gastroesophageal reflux (GER) is highly prevalent in patients with idiopathic pulmonary fibrosis (IPF). Chronic microaspiration secondary to GER may play a role in the pathogenesis and natural history of IPF. Objectives: To investigate the relationship between GER-related variables and survival time in patients with IPF. Methods: Regression analysiswasused to investigate the relationship between GER-related variables and survival time in a retrospectively identified cohort of patients with well-characterized IPF from two academic medical centers. Measurements and Main Results: Two hundred four patients were identified for inclusion. GER-related variables were common in this cohort: reported symptoms of GER (34%), a history of GER disease (45%), reported use of GER medications (47%), and Nissen fundoplication (5%). These GER-related variables were significantly associated with longer survival time on unadjusted analysis. After adjustment, the use of GER medications was an independent predictor of longer survival time. In addition, the use of gastroesophageal reflux medications was associated with a lower radiologic fibrosis score. These findings were present regardless of center. Conclusions: The reported use of GER medications is associated with decreased radiologic fibrosis and is an independent predictor of longer survival time in patients with IPF. These findings further support the hypothesis that GER and chronic microaspiration may play important roles in the pathobiology of IPF.

Original languageEnglish (US)
Pages (from-to)1390-1394
Number of pages5
JournalAmerican journal of respiratory and critical care medicine
Volume184
Issue number12
DOIs
StatePublished - Dec 15 2011

Keywords

  • Idiopathic interstitial pneumonia
  • Pulmonary fibrosis
  • Respiratory aspiration
  • Survival

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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