TY - JOUR
T1 - Gastroesophageal reflux after peroral endoscopic myotomy
T2 - A multicenter case-control study
AU - Kumbhari, Vivek
AU - Familiari, Pietro
AU - Bjerregaard, Niels Christian
AU - Pioche, Mathieu
AU - Jones, Edward
AU - Ko, Weon Jin
AU - Hayee, Bu
AU - Cali, Anna
AU - Ngamruengphong, Saowanee
AU - Mion, Francois
AU - Hernaez, Ruben
AU - Roman, Sabine
AU - Tieu, Alan H.
AU - El Zein, Mohamad
AU - Ajayi, Tokunbo
AU - Haji, Amyn
AU - Cho, Joo Young
AU - Hazey, Jeffrey
AU - Perry, Kyle A.
AU - Ponchon, Thierry
AU - Kunda, Rastislav
AU - Costamagna, Guido
AU - Khashab, Mouen A.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Background and study aims The variables associated with gastroesophageal reflux (GER) after peroral endoscopic myotomy (POEM) are largely unknown. This study aimed to: 1) identify the prevalence of reflux esophagitis and asymptomatic GER in patients who underwent POEM, and 2) evaluate patient and intraprocedural variables associated with post-POEM GER. Patients and methods All patients who underwent POEM and subsequent objective testing for GER (pH study with or without upper gastrointestinal [GI] endoscopy) at seven tertiary academic centers (one Asian, two US, four European) were included. Patients were divided into two groups: 1) DeMeester score ≥ 14.72 (cases) and 2) DeMeester score of < 14.72 (controls). Asymptomatic GER was defined as a patient with a DeMeester score ≥ 14.72 who was not consuming proton pump inhibitor (PPI). Results A total of 282 patients (female 48.2, Caucasian 84.8; mean body mass index 24.1 kg/m 2) were included. Clinical success was achieved in 94.3 of patients. GER evaluation was completed after a median follow-up of 12 months (interquartile range 10 - 24 months). A DeMeester score of ≥ 14.72 was seen in 57.8 of patients. Multivariable analysis revealed female sex to be the only independent association (odds ratio 1.69, 95 confidence interval 1.04 - 2.74) with post-POEM GER. No intraprocedural variables were associated with GER. Upper GI endoscopy was available in 233 patients, 54 (23.2) of whom were noted to have reflux esophagitis (majority Los Angeles Grade A or B). GER was asymptomatic in 60.1. Conclusion Post-POEM GER was seen in the majority of patients. No intraprocedural variables were identified to allow for potential alteration in procedural technique.
AB - Background and study aims The variables associated with gastroesophageal reflux (GER) after peroral endoscopic myotomy (POEM) are largely unknown. This study aimed to: 1) identify the prevalence of reflux esophagitis and asymptomatic GER in patients who underwent POEM, and 2) evaluate patient and intraprocedural variables associated with post-POEM GER. Patients and methods All patients who underwent POEM and subsequent objective testing for GER (pH study with or without upper gastrointestinal [GI] endoscopy) at seven tertiary academic centers (one Asian, two US, four European) were included. Patients were divided into two groups: 1) DeMeester score ≥ 14.72 (cases) and 2) DeMeester score of < 14.72 (controls). Asymptomatic GER was defined as a patient with a DeMeester score ≥ 14.72 who was not consuming proton pump inhibitor (PPI). Results A total of 282 patients (female 48.2, Caucasian 84.8; mean body mass index 24.1 kg/m 2) were included. Clinical success was achieved in 94.3 of patients. GER evaluation was completed after a median follow-up of 12 months (interquartile range 10 - 24 months). A DeMeester score of ≥ 14.72 was seen in 57.8 of patients. Multivariable analysis revealed female sex to be the only independent association (odds ratio 1.69, 95 confidence interval 1.04 - 2.74) with post-POEM GER. No intraprocedural variables were associated with GER. Upper GI endoscopy was available in 233 patients, 54 (23.2) of whom were noted to have reflux esophagitis (majority Los Angeles Grade A or B). GER was asymptomatic in 60.1. Conclusion Post-POEM GER was seen in the majority of patients. No intraprocedural variables were identified to allow for potential alteration in procedural technique.
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U2 - 10.1055/s-0043-105485
DO - 10.1055/s-0043-105485
M3 - Article
C2 - 28472834
AN - SCOPUS:85019021397
SN - 0013-726X
VL - 49
SP - 634
EP - 642
JO - Endoscopy
JF - Endoscopy
IS - 7
ER -