Gastric sensory and motor dysfunction in adolescents with functional dyspepsia

Denesh K. Chitkara, Michael Camilleri, Alan R. Zinsmeister, Duane Burton, Mounif El-Youssef, Deborah Freese, Lynn Walker, Debra Stephens

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Objectives: Validated, noninvasive studies were used to compare sensation and motor function of the upper gastrointestinal tract in adolescents with functional dyspepsia (FD) and in control subjects. Study design: Fifteen adolescents with FD and 15 healthy participants underwent standardized symptom assessment, a satiation nutrient drink test, and 13C-Spirulina platensis breath test for gastric emptying of solids. Adolescents with FD also underwent measurements of fasting and postprandial gastric volume by means of single-photon emission computed tomography, and their results were compared with those from 15 healthy volunteers (age, 18 to 25 years). Results: Compared with control subjects, adolescents with FD had significantly higher postprandial symptoms 30 minutes after reaching maximum satiation with the nutrient drink test and significant delay in the T1/2 for gastric emptying of solids. Compared with healthy 18- to 25-year-old adults, adolescents had a diminished postprandial gastric volume response. By means of single-photon emission computed tomography, frequent baseline dyspeptic symptoms were associated with prolonged T1/2 for gastric emptying and higher postprandial aggregate symptom score. A baseline increased severity of dyspepsia symptoms was associated with prolonged T1/2 for gastric emptying. Conclusions: Adolescents with FD demonstrate increased postprandial symptoms after challenge, delayed gastric emptying, and a reduced gastric volume response to feeding.

Original languageEnglish (US)
Pages (from-to)500-505
Number of pages6
JournalJournal of Pediatrics
Volume146
Issue number4
DOIs
StatePublished - Apr 2005

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Dyspepsia
Gastric Emptying
Stomach
Satiation
Single-Photon Emission-Computed Tomography
Healthy Volunteers
Spirulina
Food
Upper Gastrointestinal Tract
Breath Tests
Symptom Assessment
Fasting

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Chitkara, D. K., Camilleri, M., Zinsmeister, A. R., Burton, D., El-Youssef, M., Freese, D., ... Stephens, D. (2005). Gastric sensory and motor dysfunction in adolescents with functional dyspepsia. Journal of Pediatrics, 146(4), 500-505. https://doi.org/10.1016/j.jpeds.2004.11.031

Gastric sensory and motor dysfunction in adolescents with functional dyspepsia. / Chitkara, Denesh K.; Camilleri, Michael; Zinsmeister, Alan R.; Burton, Duane; El-Youssef, Mounif; Freese, Deborah; Walker, Lynn; Stephens, Debra.

In: Journal of Pediatrics, Vol. 146, No. 4, 04.2005, p. 500-505.

Research output: Contribution to journalArticle

Chitkara, DK, Camilleri, M, Zinsmeister, AR, Burton, D, El-Youssef, M, Freese, D, Walker, L & Stephens, D 2005, 'Gastric sensory and motor dysfunction in adolescents with functional dyspepsia', Journal of Pediatrics, vol. 146, no. 4, pp. 500-505. https://doi.org/10.1016/j.jpeds.2004.11.031
Chitkara, Denesh K. ; Camilleri, Michael ; Zinsmeister, Alan R. ; Burton, Duane ; El-Youssef, Mounif ; Freese, Deborah ; Walker, Lynn ; Stephens, Debra. / Gastric sensory and motor dysfunction in adolescents with functional dyspepsia. In: Journal of Pediatrics. 2005 ; Vol. 146, No. 4. pp. 500-505.
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