TY - JOUR
T1 - Gastric sensory and motor dysfunction in adolescents with functional dyspepsia
AU - Chitkara, Denesh K.
AU - Camilleri, Michael
AU - Zinsmeister, Alan R.
AU - Burton, Duane
AU - El-Youssef, Mounif
AU - Freese, Deborah
AU - Walker, Lynn
AU - Stephens, Debra
N1 - Funding Information:
Supported in part by the Miles and Shirley Fiterman Grant for Digestive Diseases at the Mayo Clinic, Rochester, Minnesota, National Institutes of Health grants R01-DK54681 and K24-DK02368 (M.C.), and General Clinical Research Center grant RR00585.
PY - 2005/4
Y1 - 2005/4
N2 - Objectives: Validated, noninvasive studies were used to compare sensation and motor function of the upper gastrointestinal tract in adolescents with functional dyspepsia (FD) and in control subjects. Study design: Fifteen adolescents with FD and 15 healthy participants underwent standardized symptom assessment, a satiation nutrient drink test, and 13C-Spirulina platensis breath test for gastric emptying of solids. Adolescents with FD also underwent measurements of fasting and postprandial gastric volume by means of single-photon emission computed tomography, and their results were compared with those from 15 healthy volunteers (age, 18 to 25 years). Results: Compared with control subjects, adolescents with FD had significantly higher postprandial symptoms 30 minutes after reaching maximum satiation with the nutrient drink test and significant delay in the T1/2 for gastric emptying of solids. Compared with healthy 18- to 25-year-old adults, adolescents had a diminished postprandial gastric volume response. By means of single-photon emission computed tomography, frequent baseline dyspeptic symptoms were associated with prolonged T1/2 for gastric emptying and higher postprandial aggregate symptom score. A baseline increased severity of dyspepsia symptoms was associated with prolonged T1/2 for gastric emptying. Conclusions: Adolescents with FD demonstrate increased postprandial symptoms after challenge, delayed gastric emptying, and a reduced gastric volume response to feeding.
AB - Objectives: Validated, noninvasive studies were used to compare sensation and motor function of the upper gastrointestinal tract in adolescents with functional dyspepsia (FD) and in control subjects. Study design: Fifteen adolescents with FD and 15 healthy participants underwent standardized symptom assessment, a satiation nutrient drink test, and 13C-Spirulina platensis breath test for gastric emptying of solids. Adolescents with FD also underwent measurements of fasting and postprandial gastric volume by means of single-photon emission computed tomography, and their results were compared with those from 15 healthy volunteers (age, 18 to 25 years). Results: Compared with control subjects, adolescents with FD had significantly higher postprandial symptoms 30 minutes after reaching maximum satiation with the nutrient drink test and significant delay in the T1/2 for gastric emptying of solids. Compared with healthy 18- to 25-year-old adults, adolescents had a diminished postprandial gastric volume response. By means of single-photon emission computed tomography, frequent baseline dyspeptic symptoms were associated with prolonged T1/2 for gastric emptying and higher postprandial aggregate symptom score. A baseline increased severity of dyspepsia symptoms was associated with prolonged T1/2 for gastric emptying. Conclusions: Adolescents with FD demonstrate increased postprandial symptoms after challenge, delayed gastric emptying, and a reduced gastric volume response to feeding.
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U2 - 10.1016/j.jpeds.2004.11.031
DO - 10.1016/j.jpeds.2004.11.031
M3 - Article
C2 - 15812453
AN - SCOPUS:16344390756
SN - 0022-3476
VL - 146
SP - 500
EP - 505
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 4
ER -