Gastric polyps and polyposis syndromes

Dora Lam-Himlin; Christina A. Arnold; Giovanni De Petris

doi:10.1016/j.mpdhp.2013.12.002

Gastric polyps and polyposis syndromes

Dora Lam-Himlin, Christina A. Arnold, Giovanni De Petris

Laboratory Medicine and Pathology

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Gastric polyps show significant morphologic overlap, and some polyps defy classification altogether. Nevertheless, gastric polyps, particularly when profuse, should prompt further clinical and endoscopic investigation, as it may lead to the diagnosis of a polyposis syndrome. This review summarizes the common gastric polyps that are found in familial and non-inherited polyposis syndromes of the gastrointestinal tract. Examples of the gastric polyps are illustrated, and a discussion of polyp morphology and distribution is paired with a discussion of relevant clinical features and diagnostic criteria of polyposis syndromes. This information provides pathologists guidance for further patient workup, genetic testing, and cancer surveillance.

Original language	English (US)
Pages (from-to)	1-11
Number of pages	11
Journal	Diagnostic Histopathology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.mpdhp.2013.12.002
State	Published - Jan 2014

Keywords

Cowden syndrome
Cronkhite-Cananda syndrome
Familial adenomatous polyposis
Fundic gland polyposis
Hamartomatous intestinal polyposis
Juvenile polyposis syndrome
Peutz-Jeghers syndrome

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

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10.1016/j.mpdhp.2013.12.002

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title = "Gastric polyps and polyposis syndromes",

abstract = "Gastric polyps show significant morphologic overlap, and some polyps defy classification altogether. Nevertheless, gastric polyps, particularly when profuse, should prompt further clinical and endoscopic investigation, as it may lead to the diagnosis of a polyposis syndrome. This review summarizes the common gastric polyps that are found in familial and non-inherited polyposis syndromes of the gastrointestinal tract. Examples of the gastric polyps are illustrated, and a discussion of polyp morphology and distribution is paired with a discussion of relevant clinical features and diagnostic criteria of polyposis syndromes. This information provides pathologists guidance for further patient workup, genetic testing, and cancer surveillance.",

keywords = "Cowden syndrome, Cronkhite-Cananda syndrome, Familial adenomatous polyposis, Fundic gland polyposis, Hamartomatous intestinal polyposis, Juvenile polyposis syndrome, Peutz-Jeghers syndrome",

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AU - Lam-Himlin, Dora

AU - Arnold, Christina A.

AU - De Petris, Giovanni

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N2 - Gastric polyps show significant morphologic overlap, and some polyps defy classification altogether. Nevertheless, gastric polyps, particularly when profuse, should prompt further clinical and endoscopic investigation, as it may lead to the diagnosis of a polyposis syndrome. This review summarizes the common gastric polyps that are found in familial and non-inherited polyposis syndromes of the gastrointestinal tract. Examples of the gastric polyps are illustrated, and a discussion of polyp morphology and distribution is paired with a discussion of relevant clinical features and diagnostic criteria of polyposis syndromes. This information provides pathologists guidance for further patient workup, genetic testing, and cancer surveillance.

AB - Gastric polyps show significant morphologic overlap, and some polyps defy classification altogether. Nevertheless, gastric polyps, particularly when profuse, should prompt further clinical and endoscopic investigation, as it may lead to the diagnosis of a polyposis syndrome. This review summarizes the common gastric polyps that are found in familial and non-inherited polyposis syndromes of the gastrointestinal tract. Examples of the gastric polyps are illustrated, and a discussion of polyp morphology and distribution is paired with a discussion of relevant clinical features and diagnostic criteria of polyposis syndromes. This information provides pathologists guidance for further patient workup, genetic testing, and cancer surveillance.

KW - Cowden syndrome

KW - Cronkhite-Cananda syndrome

KW - Familial adenomatous polyposis

KW - Fundic gland polyposis

KW - Hamartomatous intestinal polyposis

KW - Juvenile polyposis syndrome

KW - Peutz-Jeghers syndrome

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Gastric polyps and polyposis syndromes

Abstract

Keywords

ASJC Scopus subject areas

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