Gastric motor and sensory functions in obesity

Moo In Park, Michael Camilleri

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

In the vast majority of affected individuals, obesity involves overconsumption of food relative to calorie requirements. The sensory function of the stomach may play a key role in the cessation of food ingestion. This sensation of the stomach is, in part, determined by its motor functions, such as tone and compliance and the rate of emptying. However, studies of gastric emptying in normal-weight and obese persons have shown inconsistent results. Gastric capacity was larger in obese persons when tested with an intragastric latex balloon filled with water. In contrast, other studies using the barostat or imaging (single-photon emission computed tomography) techniques reported no differences in gastric volume or compliance between obese and lean subjects. On the other hand, increased body mass and fasting gastric volume are independently associated with delayed satiation under standard laboratory conditions of food ingestion. These data suggest that changes in gastric motor and sensory functions in obesity may present useful targets to prevent and treat obesity. Further well-controlled, validated studies are needed to clarify the potential role of altering the stomach's function as a means of controlling food intake in obesity.

Original languageEnglish (US)
Pages (from-to)491-500
Number of pages10
JournalObesity Research
Volume13
Issue number3
StatePublished - 2005

Fingerprint

Stomach
stomach
obesity
Obesity
Eating
Food
compliance
Compliance
ingestion
Satiation
gastric emptying
Gastric Emptying
Latex
latex
satiety
Single-Photon Emission-Computed Tomography
computed tomography
energy requirements
fasting
food intake

Keywords

  • Emptying
  • Food intake
  • Satiation
  • Stomach
  • Volume

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Gastric motor and sensory functions in obesity. / Park, Moo In; Camilleri, Michael.

In: Obesity Research, Vol. 13, No. 3, 2005, p. 491-500.

Research output: Contribution to journalArticle

Park, Moo In ; Camilleri, Michael. / Gastric motor and sensory functions in obesity. In: Obesity Research. 2005 ; Vol. 13, No. 3. pp. 491-500.
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