TY - JOUR
T1 - Gastric cancer in individuals with Li-Fraumeni syndrome
AU - Masciari, Serena
AU - Dewanwala, Akriti
AU - Stoffel, Elena M.
AU - Lauwers, Gregory Y.
AU - Zheng, Hui
AU - Achatz, Maria Isabel
AU - Riegert-Johnson, Douglas
AU - Foretova, Lenka
AU - Silva, Edaise M.
AU - Digianni, Lisa
AU - Verselis, Sigitas J.
AU - Schneider, Katherine
AU - Li, Frederick P.
AU - Fraumeni, Joseph
AU - Garber, Judy E.
AU - Syngal, Sapna
PY - 2011/7
Y1 - 2011/7
N2 - Purpose: Li-Fraumeni syndrome is a rare hereditary cancer syndrome associated with germline mutations in the TP53 gene. Although sarcomas, brain tumors, leukemias, breast and adrenal cortical carcinomas are typically recognized as Li-Fraumeni syndrome-associated tumors, the occurrence of gastrointestinal neoplasms has not been fully evaluated. In this analysis, we investigated the frequency and characteristics of gastric cancer in Li-Fraumeni syndrome. Methods: Pedigrees and medical records of 62 TP53 mutation-positive families were retrospectively reviewed from the Dana-Farber/National Cancer Institute Li-Fraumeni syndrome registry. We identified subjects with gastric cancer documented either by pathology report or death certificate and performed pathology review of the available specimens. Results: Among 62 TP53 mutation-positive families, there were 429 cancer-affected individuals. Gastric cancer was the diagnosis in the lineages of 21 (4.9%) subjects from 14 families (22.6%). The mean and median ages at gastric cancer diagnosis were 43 and 36 years, respectively (range: 24-74 years), significantly younger compared with the median age at diagnosis in the general population based on Surveillance Epidemiology and End Results data (71 years). Five (8.1%) families reported two or more cases of gastric cancer, and six (9.7%) families had cases of both colorectal and gastric cancers. No association was seen between phenotype and type/location of the TP53 mutations. Pathology review of the available tumors revealed both intestinal and diffuse histologies. Conclusions: Early-onset gastric cancer seems to be a component of Li-Fraumeni syndrome, suggesting the need for early and regular endoscopic screening in individuals with germline TP53 mutations, particularly among those with a family history of gastric cancer.
AB - Purpose: Li-Fraumeni syndrome is a rare hereditary cancer syndrome associated with germline mutations in the TP53 gene. Although sarcomas, brain tumors, leukemias, breast and adrenal cortical carcinomas are typically recognized as Li-Fraumeni syndrome-associated tumors, the occurrence of gastrointestinal neoplasms has not been fully evaluated. In this analysis, we investigated the frequency and characteristics of gastric cancer in Li-Fraumeni syndrome. Methods: Pedigrees and medical records of 62 TP53 mutation-positive families were retrospectively reviewed from the Dana-Farber/National Cancer Institute Li-Fraumeni syndrome registry. We identified subjects with gastric cancer documented either by pathology report or death certificate and performed pathology review of the available specimens. Results: Among 62 TP53 mutation-positive families, there were 429 cancer-affected individuals. Gastric cancer was the diagnosis in the lineages of 21 (4.9%) subjects from 14 families (22.6%). The mean and median ages at gastric cancer diagnosis were 43 and 36 years, respectively (range: 24-74 years), significantly younger compared with the median age at diagnosis in the general population based on Surveillance Epidemiology and End Results data (71 years). Five (8.1%) families reported two or more cases of gastric cancer, and six (9.7%) families had cases of both colorectal and gastric cancers. No association was seen between phenotype and type/location of the TP53 mutations. Pathology review of the available tumors revealed both intestinal and diffuse histologies. Conclusions: Early-onset gastric cancer seems to be a component of Li-Fraumeni syndrome, suggesting the need for early and regular endoscopic screening in individuals with germline TP53 mutations, particularly among those with a family history of gastric cancer.
KW - Li Fraumeni syndrome
KW - TP53
KW - gastric cancer
KW - germline mutations
KW - hereditary gastric cancer syndromes
UR - http://www.scopus.com/inward/record.url?scp=79960845375&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960845375&partnerID=8YFLogxK
U2 - 10.1097/GIM.0b013e31821628b6
DO - 10.1097/GIM.0b013e31821628b6
M3 - Article
C2 - 21552135
AN - SCOPUS:79960845375
SN - 1098-3600
VL - 13
SP - 651
EP - 657
JO - Genetics in Medicine
JF - Genetics in Medicine
IS - 7
ER -