TY - JOUR
T1 - Gastric adenocarcinoma and Helicobacter pylori infection
AU - Talley, Nicholas J.
AU - Zinsmeister, Alan R.
AU - Weaver, Amy
AU - Dimagno, Eugene P.
AU - Carpenter, Herschel A.
AU - Perez-perez, Guillermo I.
AU - Blaser, Martin J.
N1 - Funding Information:
Supported in part by Public Health Service contract CB-95601 from the Division of Cancer Biology, Diagnosis, and Centers, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, given to the Mayo National Cancer Institute Serum Bank; by the Medical Research Service of the Veterans Administration; and by The Proctor and Gamble Co.
PY - 1991/4/4
Y1 - 1991/4/4
N2 - Helicobacter pylori infection, thought to be causally related to chronic gastritis, may also be associated with an increased risk of gastric cancer. To determine whether an association with gastric cancer does exist, we retrospectively evaluated serum samples from 69 patients with histologically confirmed gastric adenocarcinoma (32 with cancer at the cardia and 37 with cancer at other sites) and from 218 patients with one of three categories of nongastric cancers, with other gastric cancers, or with benign gastric neoplasms. These samples were compared with samples from 252 cancer-free control subjects, a group comprising 76 asymptomatic volunteers and 176 persons with nonmalignant disorders. Serum samples collected from cancer patients prior to surgery and from cancer-free controls were tested for antibodies to H. pylori by using a highly sensitive and specific IgG enzyme-linked immunosorbent assay. The risk of H. pylori infection in the case patients relative to the control subjects was estimated with the use of multi-variate logistic regression analysis to adjust for potential confounding variables. Antibodies to H. pylori were detected in 65% of the patients with noncardia gastric cancer but in only 38% of the patients with gastric cancer located at the cardia. A significant association was found between H. pylori infection and noncardia gastric cancer (odds ratio = 2.67; 99% confidence interval = 1.01-7.06). Within the subset of patients with noncardia gastric cancer, a statistically nonsignificant tendency existed for those with the intestinal versus the diffuse bistologic type of noncardia gastric cancer to have a higher risk of H. pylori infection. Our results support the hypothesis of a relationship between H. pylori infection and the development of noncardia gastric adenocarcinoma. [J NatI Cancer Inst 83:1734-1739, 1991]
AB - Helicobacter pylori infection, thought to be causally related to chronic gastritis, may also be associated with an increased risk of gastric cancer. To determine whether an association with gastric cancer does exist, we retrospectively evaluated serum samples from 69 patients with histologically confirmed gastric adenocarcinoma (32 with cancer at the cardia and 37 with cancer at other sites) and from 218 patients with one of three categories of nongastric cancers, with other gastric cancers, or with benign gastric neoplasms. These samples were compared with samples from 252 cancer-free control subjects, a group comprising 76 asymptomatic volunteers and 176 persons with nonmalignant disorders. Serum samples collected from cancer patients prior to surgery and from cancer-free controls were tested for antibodies to H. pylori by using a highly sensitive and specific IgG enzyme-linked immunosorbent assay. The risk of H. pylori infection in the case patients relative to the control subjects was estimated with the use of multi-variate logistic regression analysis to adjust for potential confounding variables. Antibodies to H. pylori were detected in 65% of the patients with noncardia gastric cancer but in only 38% of the patients with gastric cancer located at the cardia. A significant association was found between H. pylori infection and noncardia gastric cancer (odds ratio = 2.67; 99% confidence interval = 1.01-7.06). Within the subset of patients with noncardia gastric cancer, a statistically nonsignificant tendency existed for those with the intestinal versus the diffuse bistologic type of noncardia gastric cancer to have a higher risk of H. pylori infection. Our results support the hypothesis of a relationship between H. pylori infection and the development of noncardia gastric adenocarcinoma. [J NatI Cancer Inst 83:1734-1739, 1991]
UR - http://www.scopus.com/inward/record.url?scp=0025987568&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025987568&partnerID=8YFLogxK
U2 - 10.1093/jnci/83.23.1734
DO - 10.1093/jnci/83.23.1734
M3 - Article
C2 - 1770552
AN - SCOPUS:0025987568
SN - 0027-8874
VL - 83
SP - 1734
EP - 1739
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 23
ER -