Gastric accommodation in non-ulcer dyspepsia and the roles of Helicobacter pylori infection and vagal function

M. Thumshirn, Michael Camilleri, S. B. Saslow, D. E. Williams, D. D. Burton, R. B. Hanson

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

Background - The pathophysiological mechanisms in non-ulcer dyspepsia are incompletely understood. Aims - To compare gastric motor and sensory functions in Helicobacter pylori positive or negative patients with non- ulcer dyspepsia. Patients - Seventeen patients with non-ulcer dyspepsia and 16 asymptomatic controls. Methods - The following were evaluated: gastrointestinal symptoms; gastric emptying and orocaecal transit of solids; abdominal vagal function; gastric compliance; fasting and postprandial gastric tone and phasic contractions; symptoms during ingestion of cold water and during the distension of an intragastric bag; and somatic sensitivity and personality profile (Minnesota Multiphasic Personality Inventory, MMPI). Results - Gastric accommodation was reduced in H pylori negative dyspeptics relative to controls; the degree of accommodation was unrelated to H pylori status in dyspeptics. Increased postprandial gastric sensation was more frequent among H pylori positive patients (4/5 H pylori positive versus 4/12 H pylori negative patients). Intragastric meal distribution and orocaecal transit were normal; gastric emptying at four hours was abnormal in 4/17 patients. Vagal dysfunction was rare. Eight of 17 patients had somatisation or depression on MMPI. Conclusion - Impaired gastric accommodation is frequent in non-ulcer dyspepsia and seems to be unrelated to vagal efferent dysfunction. H pylori infection does not seem to influence gastric accommodation, but is associated with heightened sensitivity in dyspeptics. Therapeutic approaches that restore normal postprandial accommodation and gastric sensitivity should be tested in non-ulcer dyspepsia.

Original languageEnglish (US)
Pages (from-to)55-64
Number of pages10
JournalGut
Volume44
Issue number1
StatePublished - 1999

Fingerprint

Dyspepsia
Helicobacter Infections
Helicobacter pylori
Pylorus
Stomach
MMPI
Gastric Emptying
Compliance
Ulcer
Meals
Personality
Fasting
Eating
Depression
Water
Infection

Keywords

  • Helicobacter pylori
  • Non-ulcer dyspepsia
  • Vagal function

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Thumshirn, M., Camilleri, M., Saslow, S. B., Williams, D. E., Burton, D. D., & Hanson, R. B. (1999). Gastric accommodation in non-ulcer dyspepsia and the roles of Helicobacter pylori infection and vagal function. Gut, 44(1), 55-64.

Gastric accommodation in non-ulcer dyspepsia and the roles of Helicobacter pylori infection and vagal function. / Thumshirn, M.; Camilleri, Michael; Saslow, S. B.; Williams, D. E.; Burton, D. D.; Hanson, R. B.

In: Gut, Vol. 44, No. 1, 1999, p. 55-64.

Research output: Contribution to journalArticle

Thumshirn, M, Camilleri, M, Saslow, SB, Williams, DE, Burton, DD & Hanson, RB 1999, 'Gastric accommodation in non-ulcer dyspepsia and the roles of Helicobacter pylori infection and vagal function', Gut, vol. 44, no. 1, pp. 55-64.
Thumshirn, M. ; Camilleri, Michael ; Saslow, S. B. ; Williams, D. E. ; Burton, D. D. ; Hanson, R. B. / Gastric accommodation in non-ulcer dyspepsia and the roles of Helicobacter pylori infection and vagal function. In: Gut. 1999 ; Vol. 44, No. 1. pp. 55-64.
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