Gasotransmitters in the gastrointestinal tract

Michael S. Kasparek, David R Linden, Martin E. Kreis, Michael G. Sarr

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Mechanisms of cell-to-cell signaling take many forms: classic receptor-mediated transmission, opening and/or closing of ion channels, and this new concept of gasotransmitters that diffuse into the cell to exert their effects after being released by neural stimulation, inflammatory cells, or even bacteria. NO, CO, and H2S are the three gasotransmitters that have pioneered the latter group of signal molecules. Future work is expected to solidify our understanding of their mechanisms of action, delineate their interaction, and define their roles in normal physiology as well as pathophysiology.

Original languageEnglish (US)
Pages (from-to)455-459
Number of pages5
JournalSurgery
Volume143
Issue number4
DOIs
StatePublished - Apr 2008

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Gasotransmitters
Gastrointestinal Tract
Carbon Monoxide
Ion Channels
Bacteria

ASJC Scopus subject areas

  • Surgery

Cite this

Kasparek, M. S., Linden, D. R., Kreis, M. E., & Sarr, M. G. (2008). Gasotransmitters in the gastrointestinal tract. Surgery, 143(4), 455-459. https://doi.org/10.1016/j.surg.2007.10.017

Gasotransmitters in the gastrointestinal tract. / Kasparek, Michael S.; Linden, David R; Kreis, Martin E.; Sarr, Michael G.

In: Surgery, Vol. 143, No. 4, 04.2008, p. 455-459.

Research output: Contribution to journalArticle

Kasparek, MS, Linden, DR, Kreis, ME & Sarr, MG 2008, 'Gasotransmitters in the gastrointestinal tract', Surgery, vol. 143, no. 4, pp. 455-459. https://doi.org/10.1016/j.surg.2007.10.017
Kasparek, Michael S. ; Linden, David R ; Kreis, Martin E. ; Sarr, Michael G. / Gasotransmitters in the gastrointestinal tract. In: Surgery. 2008 ; Vol. 143, No. 4. pp. 455-459.
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