Gasotransmitters in the gastrointestinal tract

Michael S. Kasparek, David R. Linden, Martin E. Kreis, Michael G. Sarr

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


Mechanisms of cell-to-cell signaling take many forms: classic receptor-mediated transmission, opening and/or closing of ion channels, and this new concept of gasotransmitters that diffuse into the cell to exert their effects after being released by neural stimulation, inflammatory cells, or even bacteria. NO, CO, and H2S are the three gasotransmitters that have pioneered the latter group of signal molecules. Future work is expected to solidify our understanding of their mechanisms of action, delineate their interaction, and define their roles in normal physiology as well as pathophysiology.

Original languageEnglish (US)
Pages (from-to)455-459
Number of pages5
Issue number4
StatePublished - Apr 2008

ASJC Scopus subject areas

  • Surgery


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