TY - JOUR
T1 - Gasotransmitters in the gastrointestinal tract
AU - Kasparek, Michael S.
AU - Linden, David R.
AU - Kreis, Martin E.
AU - Sarr, Michael G.
PY - 2008/4
Y1 - 2008/4
N2 - Mechanisms of cell-to-cell signaling take many forms: classic receptor-mediated transmission, opening and/or closing of ion channels, and this new concept of gasotransmitters that diffuse into the cell to exert their effects after being released by neural stimulation, inflammatory cells, or even bacteria. NO, CO, and H2S are the three gasotransmitters that have pioneered the latter group of signal molecules. Future work is expected to solidify our understanding of their mechanisms of action, delineate their interaction, and define their roles in normal physiology as well as pathophysiology.
AB - Mechanisms of cell-to-cell signaling take many forms: classic receptor-mediated transmission, opening and/or closing of ion channels, and this new concept of gasotransmitters that diffuse into the cell to exert their effects after being released by neural stimulation, inflammatory cells, or even bacteria. NO, CO, and H2S are the three gasotransmitters that have pioneered the latter group of signal molecules. Future work is expected to solidify our understanding of their mechanisms of action, delineate their interaction, and define their roles in normal physiology as well as pathophysiology.
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U2 - 10.1016/j.surg.2007.10.017
DO - 10.1016/j.surg.2007.10.017
M3 - Review article
C2 - 18374039
AN - SCOPUS:40949103593
SN - 0039-6060
VL - 143
SP - 455
EP - 459
JO - Surgery (United States)
JF - Surgery (United States)
IS - 4
ER -