Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes

Marc Tjwa; Lola Bellido-Martin; Yuan Lin; Esther Lutgens; Stéphane Plaisance; Françoise Bono; Nathalie Delesque-Touchard; Caroline Hervé; Rute Moura; An D. Billiau; Cristina Aparicio; Marcel Levi; Mat Daemen; Mieke Dewerchin; Florea Lupu; Jef Arnout; Jean Marc Herbert; Mark Waer; Pablo García De Frutos; Björn Dahlbäck; Peter Carmeliet; Marc F. Hoylaerts; Lieve Moons

doi:10.1182/blood-2007-05-089565

Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes

Marc Tjwa, Lola Bellido-Martin, Yuan Lin, Esther Lutgens, Stéphane Plaisance, Françoise Bono, Nathalie Delesque-Touchard, Caroline Hervé, Rute Moura, An D. Billiau, Cristina Aparicio, Marcel Levi, Mat Daemen, Mieke Dewerchin, Florea Lupu, Jef Arnout, Jean Marc Herbert, Mark Waer, Pablo García De Frutos, Björn DahlbäckPeter Carmeliet, Marc F. Hoylaerts, Lieve Moons

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and endothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart trans plantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.

Original language	English (US)
Pages (from-to)	4096-4105
Number of pages	10
Journal	Blood
Volume	111
Issue number	8
DOIs	https://doi.org/10.1182/blood-2007-05-089565
State	Published - Apr 15 2008

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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10.1182/blood-2007-05-089565

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Tjwa, M., Bellido-Martin, L., Lin, Y., Lutgens, E., Plaisance, S., Bono, F., Delesque-Touchard, N., Hervé, C., Moura, R., Billiau, A. D., Aparicio, C., Levi, M., Daemen, M., Dewerchin, M., Lupu, F., Arnout, J., Herbert, J. M., Waer, M., De Frutos, P. G., ... Moons, L. (2008). Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes. Blood, 111(8), 4096-4105. https://doi.org/10.1182/blood-2007-05-089565

Tjwa, M, Bellido-Martin, L, Lin, Y, Lutgens, E, Plaisance, S, Bono, F, Delesque-Touchard, N, Hervé, C, Moura, R, Billiau, AD, Aparicio, C, Levi, M, Daemen, M, Dewerchin, M, Lupu, F, Arnout, J, Herbert, JM, Waer, M, De Frutos, PG, Dahlbäck, B, Carmeliet, P, Hoylaerts, MF & Moons, L 2008, 'Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes', Blood, vol. 111, no. 8, pp. 4096-4105. https://doi.org/10.1182/blood-2007-05-089565

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title = "Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes",

abstract = "The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and endothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart trans plantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.",

author = "Marc Tjwa and Lola Bellido-Martin and Yuan Lin and Esther Lutgens and St{\'e}phane Plaisance and Fran{\c c}oise Bono and Nathalie Delesque-Touchard and Caroline Herv{\'e} and Rute Moura and Billiau, {An D.} and Cristina Aparicio and Marcel Levi and Mat Daemen and Mieke Dewerchin and Florea Lupu and Jef Arnout and Herbert, {Jean Marc} and Mark Waer and {De Frutos}, {Pablo Garc{\'i}a} and Bj{\"o}rn Dahlb{\"a}ck and Peter Carmeliet and Hoylaerts, {Marc F.} and Lieve Moons",

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doi = "10.1182/blood-2007-05-089565",

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T1 - Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes

AU - Tjwa, Marc

AU - Bellido-Martin, Lola

AU - Lin, Yuan

AU - Lutgens, Esther

AU - Plaisance, Stéphane

AU - Bono, Françoise

AU - Delesque-Touchard, Nathalie

AU - Hervé, Caroline

AU - Moura, Rute

AU - Billiau, An D.

AU - Aparicio, Cristina

AU - Levi, Marcel

AU - Daemen, Mat

AU - Dewerchin, Mieke

AU - Lupu, Florea

AU - Arnout, Jef

AU - Herbert, Jean Marc

AU - Waer, Mark

AU - De Frutos, Pablo García

AU - Dahlbäck, Björn

AU - Carmeliet, Peter

AU - Hoylaerts, Marc F.

AU - Moons, Lieve

PY - 2008/4/15

Y1 - 2008/4/15

N2 - The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and endothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart trans plantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.

AB - The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and endothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart trans plantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.

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JO - Blood

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SN - 0006-4971

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ER -

Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes

Abstract

ASJC Scopus subject areas

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