Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes

Marc Tjwa, Lola Bellido-Martin, Yuan Lin, Esther Lutgens, Stéphane Plaisance, Françoise Bono, Nathalie Delesque-Touchard, Caroline Hervé, Rute Moura, An D. Billiau, Cristina Aparicio, Marcel Levi, Mat Daemen, Mieke Dewerchin, Florea Lupu, Jef Arnout, Jean Marc Herbert, Mark Waer, Pablo García De Frutos, Björn DahlbäckPeter Carmeliet, Marc F. Hoylaerts, Lieve Moons

Research output: Contribution to journalArticlepeer-review

Abstract

The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and endothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart trans plantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.

Original languageEnglish (US)
Pages (from-to)4096-4105
Number of pages10
JournalBlood
Volume111
Issue number8
DOIs
StatePublished - Apr 15 2008

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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