TY - JOUR
T1 - Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes
AU - Tjwa, Marc
AU - Bellido-Martin, Lola
AU - Lin, Yuan
AU - Lutgens, Esther
AU - Plaisance, Stéphane
AU - Bono, Françoise
AU - Delesque-Touchard, Nathalie
AU - Hervé, Caroline
AU - Moura, Rute
AU - Billiau, An D.
AU - Aparicio, Cristina
AU - Levi, Marcel
AU - Daemen, Mat
AU - Dewerchin, Mieke
AU - Lupu, Florea
AU - Arnout, Jef
AU - Herbert, Jean Marc
AU - Waer, Mark
AU - De Frutos, Pablo García
AU - Dahlbäck, Björn
AU - Carmeliet, Peter
AU - Hoylaerts, Marc F.
AU - Moons, Lieve
PY - 2008/4/15
Y1 - 2008/4/15
N2 - The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and endothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart trans plantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.
AB - The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In vivo, Gas6 promotes and accelerates the sequestration of circulating platelets and leukocytes on activated endothelium as well as the formation and endothelial sequestration of circulating platelet-leukocyte conjugates. In addition, Gas6 promotes leukocyte extravasation, inflammation, and thrombosis in mouse models of inflammation (endotoxinemia, vasculitis, heart trans plantation). Thus, Gas6 amplifies EC activation, thereby playing a key role in enhancing the interactions between ECs, platelets, and leukocytes during inflammation.
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U2 - 10.1182/blood-2007-05-089565
DO - 10.1182/blood-2007-05-089565
M3 - Article
C2 - 18156494
AN - SCOPUS:43249087544
VL - 111
SP - 4096
EP - 4105
JO - Blood
JF - Blood
SN - 0006-4971
IS - 8
ER -