Gamma/delta T-cell posttransplantation lymphoproliferative disorder primarily in the spleen

C. W. Ross, B. Schnitzer, S. Sheldon, D. K. Braun, C. A. Hanson

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

A 31-year-old renal transplant recipient developed an unusual T-cell lymphoproliferative disorder 3 years after transplantation. The neoplasm involved the spleen, without concomitant hepatomegaly, lymphadenopathy, or obvious bone marrow involvement. Peripheral blood involvement developed after splenectomy. Immunophenotypically, the neoplastic cells expressed CD2, CD3, CD7, CD16, CD45, CD56, and the γ/δ T-cell receptor on the surface membrane. The neoplastic cells were negative for surface membrane CD4, CD5, and CD8. Serologic and/or DNA analyses for viruses, including Epstein-Barr virus, human T-cell lymphotropic virus-1, human immunodeficiency virus, and human herpesvirus-6, were negative. Cytogenetic findings included a translocation breakpoint at chromosome 7p15, consistent with involvement of the T-cell receptor γ-chain locus. Although γ/δ T-cell lymphomas have been reported to have a predilection for hepatosplenic localization, this is the first well-documented case to be described in the setting of posttransplantation immunosuppression.

Original languageEnglish (US)
Pages (from-to)310-315
Number of pages6
JournalAmerican journal of clinical pathology
Volume102
Issue number3
DOIs
StatePublished - Jan 1 1994

Keywords

  • Spleen
  • T-Cell lymphoma
  • Transplantation
  • γ/δ T-Cell receptor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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