Gamma knife irradition-Induced changes in the normal rat brain studied with 1H magnetic resonance spectroscopy and imaging

Reed A. Omary, Stuart S. Berr, Toshifumi Kamiryo, Giuseppe Lanzino, Neal F. Kassell, Kevin S. Lee, M. Beatriz Lopes, Bruce J. Hillman

Research output: Contribution to journalArticle

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Abstract

Rationale and Objectives.: The pathogenesis of brain injury following radiosurgery is poorly understood. To better elucidate the relationship between blood-brain barrier disruption and metabolic derangements, we used magnetic resonance (MR) imaging and 1H MR spectroscopy to detect early changes from focused single-fraction, high-dose irradiation injury in rat brains. Methods.: Using the Leksell gamma knife, we irradiated the frontoparietal cortex of 11 male Wistar rats with a single dose of 120 Gy. Four weeks later, we sequentially performed water-suppressed 1H MR spectroscopy and gadopentetate dimeglumine-enhanced T1-weighted MR imaging. Metabolic maps were created of n-acetylaspartate (NAA), creatine and choline (Cr/Cho), and lactate from the MR spectroscopy data set. Detection of irradiation injury among the tested modalities was assessed by receiver operating characteristic analysis and by quantitative signal intensity changes. Pathologic confirmation of irradiation damage was obtained in all rats. Results.: Gadopentetate dimeglumine-enhanced T1-weighted MR imaging was the only imaging modality that detected statistically significant signal intensity changes (p < .05). No reproducible changes in the metabolites of interest could be detected by 1H MR spectroscopy. Conclusion.: In our animal model, blood-brain barrier disruption was a reproducible, integral finding of single-fraction, high-dose irradiation injury. No reproducible metabolic derangements of ischemia or necrosis were detected by 1H MR spectroscopy, possibly because of dose-latency effects or sensitivity issues.

Original languageEnglish (US)
Pages (from-to)1043-1051
Number of pages9
JournalAcademic Radiology
Volume2
Issue number12
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Brain
Gadolinium DTPA
Blood-Brain Barrier
Wounds and Injuries
Creatine
Radiosurgery
Choline
ROC Curve
Brain Injuries
Wistar Rats
Lactic Acid
Necrosis
Ischemia
Animal Models
Water

Keywords

  • gamma knife
  • magnetic resonance imaging
  • magnetic resonance spectroscopy
  • radiosurgery
  • Rat brain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Omary, R. A., Berr, S. S., Kamiryo, T., Lanzino, G., Kassell, N. F., Lee, K. S., ... Hillman, B. J. (1995). Gamma knife irradition-Induced changes in the normal rat brain studied with 1H magnetic resonance spectroscopy and imaging. Academic Radiology, 2(12), 1043-1051. https://doi.org/10.1016/S1076-6332(05)80511-2

Gamma knife irradition-Induced changes in the normal rat brain studied with 1H magnetic resonance spectroscopy and imaging. / Omary, Reed A.; Berr, Stuart S.; Kamiryo, Toshifumi; Lanzino, Giuseppe; Kassell, Neal F.; Lee, Kevin S.; Beatriz Lopes, M.; Hillman, Bruce J.

In: Academic Radiology, Vol. 2, No. 12, 1995, p. 1043-1051.

Research output: Contribution to journalArticle

Omary, RA, Berr, SS, Kamiryo, T, Lanzino, G, Kassell, NF, Lee, KS, Beatriz Lopes, M & Hillman, BJ 1995, 'Gamma knife irradition-Induced changes in the normal rat brain studied with 1H magnetic resonance spectroscopy and imaging', Academic Radiology, vol. 2, no. 12, pp. 1043-1051. https://doi.org/10.1016/S1076-6332(05)80511-2
Omary, Reed A. ; Berr, Stuart S. ; Kamiryo, Toshifumi ; Lanzino, Giuseppe ; Kassell, Neal F. ; Lee, Kevin S. ; Beatriz Lopes, M. ; Hillman, Bruce J. / Gamma knife irradition-Induced changes in the normal rat brain studied with 1H magnetic resonance spectroscopy and imaging. In: Academic Radiology. 1995 ; Vol. 2, No. 12. pp. 1043-1051.
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AU - Berr, Stuart S.

AU - Kamiryo, Toshifumi

AU - Lanzino, Giuseppe

AU - Kassell, Neal F.

AU - Lee, Kevin S.

AU - Beatriz Lopes, M.

AU - Hillman, Bruce J.

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N2 - Rationale and Objectives.: The pathogenesis of brain injury following radiosurgery is poorly understood. To better elucidate the relationship between blood-brain barrier disruption and metabolic derangements, we used magnetic resonance (MR) imaging and 1H MR spectroscopy to detect early changes from focused single-fraction, high-dose irradiation injury in rat brains. Methods.: Using the Leksell gamma knife, we irradiated the frontoparietal cortex of 11 male Wistar rats with a single dose of 120 Gy. Four weeks later, we sequentially performed water-suppressed 1H MR spectroscopy and gadopentetate dimeglumine-enhanced T1-weighted MR imaging. Metabolic maps were created of n-acetylaspartate (NAA), creatine and choline (Cr/Cho), and lactate from the MR spectroscopy data set. Detection of irradiation injury among the tested modalities was assessed by receiver operating characteristic analysis and by quantitative signal intensity changes. Pathologic confirmation of irradiation damage was obtained in all rats. Results.: Gadopentetate dimeglumine-enhanced T1-weighted MR imaging was the only imaging modality that detected statistically significant signal intensity changes (p < .05). No reproducible changes in the metabolites of interest could be detected by 1H MR spectroscopy. Conclusion.: In our animal model, blood-brain barrier disruption was a reproducible, integral finding of single-fraction, high-dose irradiation injury. No reproducible metabolic derangements of ischemia or necrosis were detected by 1H MR spectroscopy, possibly because of dose-latency effects or sensitivity issues.

AB - Rationale and Objectives.: The pathogenesis of brain injury following radiosurgery is poorly understood. To better elucidate the relationship between blood-brain barrier disruption and metabolic derangements, we used magnetic resonance (MR) imaging and 1H MR spectroscopy to detect early changes from focused single-fraction, high-dose irradiation injury in rat brains. Methods.: Using the Leksell gamma knife, we irradiated the frontoparietal cortex of 11 male Wistar rats with a single dose of 120 Gy. Four weeks later, we sequentially performed water-suppressed 1H MR spectroscopy and gadopentetate dimeglumine-enhanced T1-weighted MR imaging. Metabolic maps were created of n-acetylaspartate (NAA), creatine and choline (Cr/Cho), and lactate from the MR spectroscopy data set. Detection of irradiation injury among the tested modalities was assessed by receiver operating characteristic analysis and by quantitative signal intensity changes. Pathologic confirmation of irradiation damage was obtained in all rats. Results.: Gadopentetate dimeglumine-enhanced T1-weighted MR imaging was the only imaging modality that detected statistically significant signal intensity changes (p < .05). No reproducible changes in the metabolites of interest could be detected by 1H MR spectroscopy. Conclusion.: In our animal model, blood-brain barrier disruption was a reproducible, integral finding of single-fraction, high-dose irradiation injury. No reproducible metabolic derangements of ischemia or necrosis were detected by 1H MR spectroscopy, possibly because of dose-latency effects or sensitivity issues.

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