Abstract
Administration of neutralizing monoclonal antibody to gamma interferon increased Theiler's virus-induced demyelination and virus antigen persistence in the spinal cord in susceptible SJL/J mice and completely abrogated resistance such that all C57BL/10SNJ mice developed demyelination. These experiments support the hypothesis that gamma interferon is critically important for resistance to Theiler's virus-induced disease but is not required for myelin destruction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 7286-7290 |
| Number of pages | 5 |
| Journal | Journal of virology |
| Volume | 69 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1995 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology