Gamma interferon is critical for resistance to Theiler's virus-induced demyelination

Moses Rodriguez, Kevin Pavelko, Robert L. Coffman

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

Administration of neutralizing monoclonal antibody to gamma interferon increased Theiler's virus-induced demyelination and virus antigen persistence in the spinal cord in susceptible SJL/J mice and completely abrogated resistance such that all C57BL/10SNJ mice developed demyelination. These experiments support the hypothesis that gamma interferon is critically important for resistance to Theiler's virus-induced disease but is not required for myelin destruction.

Original languageEnglish (US)
Pages (from-to)7286-7290
Number of pages5
JournalJournal of virology
Volume69
Issue number11
DOIs
StatePublished - Nov 1995

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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